Emerging strategies for the identification and targeting of cancer stem cells

被引：72
作者：
Dou, Jun [1 ]
Gu, Ning [2 ]
机构：
[1] Southeast Univ, Dept Pathogen Biol & Immunol, Sch Basic Med Sci, Nanjing 210009, Peoples R China
[2] Southeast Univ, Sch Biol Sci & Med Engn, Nanjing 210096, Peoples R China
来源：
TUMOR BIOLOGY | 2010年 / 31卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Cancer stem cells; Challenge; Strategy; HEPATOCELLULAR-CARCINOMA CELLS; DISTINCT SIDE POPULATION; DOWN-REGULATION; BETA-CATENIN; MELANOMA; GLIOMA; CD133; RESISTANCE; EXPRESSION; TRANSPORT;
D O I：
10.1007/s13277-010-0023-y
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The hypothesis of cancer stem cells (CSCs) is receiving increasing interest and has become the subject of considerable debate among cancer researchers. Recent rapid progress in CSC research has encountered increasing difficulties and challenges. Understanding the biologic characteristic of CSCs is crucial to start with better identification and diagnosis based on CSC markers and eventually targeting to CSCs will undoubtedly result in improved prevention and treatment of many types of CSCs. We discuss here some of the approaching strategies that include establishing special methods of identifying CSCs and targeting therapies of CSCs.
引用
收藏
页码：243 / 253
页数：11
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