Moving bronchopulmonary dysplasia research from the bedside to the bench

被引:12
作者
Gilfillan, Margaret [1 ]
Bhandari, Vineet [2 ]
机构
[1] Drexel Univ, Coll Med, St Christophers Hosp Children, Div Neonatol, Philadelphia, PA USA
[2] Rowan Univ, Cooper Med Sch, Childrens Reg Hosp, Div Neonatol, Camden, NJ 08102 USA
关键词
animal models; caffeine; noninvasive ventilation; postnatal steroids; pulmonary hypertension; LOW-BIRTH-WEIGHT; MIGRATION INHIBITORY FACTOR; FREQUENCY OSCILLATORY VENTILATION; VITAMIN-A SUPPLEMENTATION; CHRONIC LUNG-DISEASE; RESPIRATORY-TRACT COLONIZATION; EARLY ADRENAL INSUFFICIENCY; EXTREMELY PRETERM INFANTS; LOW-DOSE HYDROCORTISONE; PULMONARY-HYPERTENSION;
D O I
10.1152/ajplung.00452.2021
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Although advances in the respiratory management of extremely preterm infants have led to improvements in survival, this progress has not yet extended to a reduction in the incidence of bronchopulmonary dysplasia (BPD). BPD is a complex multifactorial condition that primarily occurs due to disturbances in the regulation of normal pulmonary airspace and vascular development Preterm birth and exposure to invasive mechanical ventilation also compromises large airway development, leading to significant morbidity and mortality. Although both predisposing and protective genetic and environmental factors have been frequently described in the clinical literature, these findings have had limited impact on the development of effective therapeutic strategies. This gap is likely because the molecular pathways that underlie these observations are yet not fully understood, limiting the ability of researchers to identify novel treatments that can preserve normal lung development and/or enhance cellular repair mechanisms. In this review article, we will outline various well-established clinical observations while identifying key knowledge gaps that need to be filled with carefully designed preclinical experiments. We will address these issues by discussing controversial topics in the pathophysiology, the pathology, and the treatment of BPD, including an evaluation of existing animal models that have been used to answer important questions.
引用
收藏
页码:L804 / L821
页数:18
相关论文
共 50 条
  • [41] Fetal Vascular Origins of Bronchopulmonary Dysplasia
    Mandell, Erica W.
    Abman, Steven H.
    [J]. JOURNAL OF PEDIATRICS, 2017, 185 : 7 - +
  • [42] Short- and Long-Term Complications of Bronchopulmonary Dysplasia
    Homan, Travis D.
    Nayak, Ravi P.
    [J]. RESPIRATORY CARE, 2021, 66 (10) : 1618 - 1629
  • [43] Corticosteroids for the prevention and treatment of bronchopulmonary dysplasia: an overview of systematic reviews
    van de Loo, Moniek
    Van Kaam, Anton
    Offringa, Martin
    Doyle, Lex W.
    Cooper, Chris
    Onland, Wes
    [J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2024, (04):
  • [44] Cellular and humoral biomarkers of Bronchopulmonary Dysplasia
    Lal, Charitharth Vivek
    Ambalavanan, Namasivayam
    [J]. EARLY HUMAN DEVELOPMENT, 2017, 105 : 35 - 39
  • [45] Bronchopulmonary Dysplasia: Executive Summary of a Workshop
    Higgins, Rosemary D.
    Jobe, Alan H.
    Koso-Thomas, Marion
    Bancalari, Eduardo
    Viscardi, Rose M.
    Hartert, Tina, V
    Ryan, Rita M.
    Kallapur, Suhas G.
    Steinhorn, Robin H.
    Konduri, Girija G.
    Davis, Stephanie D.
    Thebaud, Bernard
    Clyman, Onald, I
    Collaco, Joseph M.
    Martin, Camilia R.
    Woods, Jason C.
    Finer, Neil N.
    Raju, Tonse N. K.
    [J]. JOURNAL OF PEDIATRICS, 2018, 197 : 300 - 308
  • [46] The economic impact of prematurity and bronchopulmonary dysplasia
    Alvarez-Fuente, Maria
    Arruza, Luis
    Muro, Marta
    Zozaya, Carlos
    Avila, Alejandro
    Lopez-Ortego, Paloma
    Gonzalez-Armengod, Carmen
    Torrent, Alba
    Luis Gavilan, Jose
    Jesus del Cerro, Maria
    [J]. EUROPEAN JOURNAL OF PEDIATRICS, 2017, 176 (12) : 1587 - 1593
  • [47] Weaning oxygen in infants with bronchopulmonary dysplasia
    Everitt, Lucy H.
    Awoseyila, Adejumoke
    Bhatt, Jayesh M.
    Johnson, Mark J.
    Vollmer, Brigitte
    Evans, Hazel J.
    [J]. PAEDIATRIC RESPIRATORY REVIEWS, 2021, 39 : 82 - 89
  • [48] The 'new' bronchopulmonary dysplasia: challenges and commentary
    Merritt, T. Allen
    Deming, Douglas D.
    Boynton, Bruce R.
    [J]. SEMINARS IN FETAL & NEONATAL MEDICINE, 2009, 14 (06) : 345 - 357
  • [49] Cardiovascular impact and sequelae of bronchopulmonary dysplasia
    Yallapragada, Sushmita G.
    Savani, Rashmin C.
    Goss, Kara N.
    [J]. PEDIATRIC PULMONOLOGY, 2021, 56 (11) : 3453 - 3463
  • [50] Pharmacotherapy in Bronchopulmonary Dysplasia: What Is the Evidence?
    Sakaria, Rishika P.
    Dhanireddy, Ramasubbareddy
    [J]. FRONTIERS IN PEDIATRICS, 2022, 10