Sestrins at the crossroad between stress and aging

被引：58

作者：

Lee, Jun Hee ^{[2
,3
]}

Bodmer, Rolf ^{[4
]}

Bier, Ethan ^{[1
]}

Karin, Michael ^{[2
,3
]}

机构：

[1] Univ Calif San Diego, Sect Cell & Dev Biol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Sch Med, Dept Pathol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

[4] Sanford Burnham Med Res Inst, Neurosci Aging & Stem Cell Res Ctr, Dev & Aging Program, La Jolla, CA 92037 USA

来源：

AGING-US | 2010年 / 2卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Sestrin; TOR; autophagy; stress; aging; hormesis; OXIDATIVE STRESS; LIFE-SPAN; HEART FUNCTION; DNA-DAMAGE; DROSOPHILA; P53; AUTOPHAGY; MTOR; GENE; PATHWAYS;

D O I：

10.18632/aging.100157

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced pathophysiological contexts that can result in premature aging and age-related diseases. We suggest that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints.

引用

页码：369 / 374

页数：6

共 61 条

[1] The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman [J].

Akasaka, Takeshi ;

Klinedinst, Susan ;

Ocorr, Karen ;

Bustamante, Erika L. ;

Kim, Seung K. ;

Bodmer, Rolf .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (32) :11999-12004

[2]

[Anonymous], 2014, World Health Report 2014

[3] Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression [J].

Bonawitz, Nicholas D. ;

Chatenay-Lapointe, Marc ;

Pan, Yong ;

Shadel, Gerald S. .

CELL METABOLISM, 2007, 5 (04) :265-277

[4] p53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling [J].

Budanov, Andrei V. ;

Karin, Michael .

CELL, 2008, 134 (03) :451-460

[5] Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD [J].

Budanov, AV ;

Sablina, AA ;

Feinstein, E ;

Koonin, EV ;

Chumakov, PM .

SCIENCE, 2004, 304 (5670) :596-600

[6] Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability [J].

Budanov, AV ;

Shoshani, T ;

Faerman, A ;

Zelin, E ;

Kamer, I ;

Kalinski, H ;

Gorodin, S ;

Fishman, A ;

Chajut, A ;

Einat, P ;

Skaliter, R ;

Gudkov, AV ;

Chumakov, PM ;

Feinstein, E .

ONCOGENE, 2002, 21 (39) :6017-6031

[7] Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles [J].

Cammarato, Anthony ;

Dambacher, Corey M. ;

Knowles, Aileen F. ;

Kronert, William A. ;

Bodmer, Rolf ;

Ocorr, Karen ;

Bernstein, Sanford I. .

MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (02) :553-562

[8] Review article: diabetes, genetics and ethnicity [J].

Carulli, L ;

Rondinella, S ;

Lombardini, S ;

Canedi, I ;

Loria, P ;

Carulli, N .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2005, 22 :16-19

[9] mTORC1 Phosphorylates the ULK1-mAtg13-FIP200 Autophagy Regulatory Complex [J].

Chan, Edmond Y. .

SCIENCE SIGNALING, 2009, 2 (84)

[10] Evolution of genes and genomes on the Drosophila phylogeny [J].

Clark, Andrew G. ;

Eisen, Michael B. ;

Smith, Douglas R. ;

Bergman, Casey M. ;

Oliver, Brian ;

Markow, Therese A. ;

Kaufman, Thomas C. ;

Kellis, Manolis ;

Gelbart, William ;

Iyer, Venky N. ;

Pollard, Daniel A. ;

Sackton, Timothy B. ;

Larracuente, Amanda M. ;

Singh, Nadia D. ;

Abad, Jose P. ;

Abt, Dawn N. ;

Adryan, Boris ;

Aguade, Montserrat ;

Akashi, Hiroshi ;

Anderson, Wyatt W. ;

Aquadro, Charles F. ;

Ardell, David H. ;

Arguello, Roman ;

Artieri, Carlo G. ;

Barbash, Daniel A. ;

Barker, Daniel ;

Barsanti, Paolo ;

Batterham, Phil ;

Batzoglou, Serafim ;

Begun, Dave ;

Bhutkar, Arjun ;

Blanco, Enrico ;

Bosak, Stephanie A. ;

Bradley, Robert K. ;

Brand, Adrianne D. ;

Brent, Michael R. ;

Brooks, Angela N. ;

Brown, Randall H. ;

Butlin, Roger K. ;

Caggese, Corrado ;

Calvi, Brian R. ;

de Carvalho, A. Bernardo ;

Caspi, Anat ;

Castrezana, Sergio ;

Celniker, Susan E. ;

Chang, Jean L. ;

Chapple, Charles ;

Chatterji, Sourav ;

Chinwalla, Asif ;

Civetta, Alberto .

NATURE, 2007, 450 (7167) :203-218

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