Spiroalanfurantones A-D, Four Eudesmanolide-Furan Sesquiterpene Adducts with a Pentacyclic 6/6/5/5/5 Skeleton from Inula helenium

被引：13

作者：

Cai, You-Sheng ^{[1
]}

Wu, Zi ^{[1
]}

Wang, Jian-Rong ^{[2
]}

Zheng, Xiao-Qin ^{[1
]}

Xu, Jie ^{[1
]}

Qiu, Guofu ^{[1
]}

Yu, Jianqing ^{[1
]}

机构：

[1] Wuhan Univ, Inst TCM & Nat Prod, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 23期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

LACTONE DIMERS; ROOTS; CYTOTOXICITY;

D O I：

10.1021/acs.orglett.9b03676

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Spiroalanfurantones A-D (1-4), four eudesmanolide-furan sesquiterpene adducts with an unprecedented pentacyclic 6/6/5/5/5 skeleton, were isolated from the roots of Inula helenium. Their structures were elucidated by spectroscopic data analysis and single-crystal X-ray diffraction analysis. The plausible biosynthetic pathway for 1-4 is presented. Bioassay showed that compounds 1 and 2 significantly inhibited nitric oxide production in lipopolysaccharide-induced RAW264.7 macrophages with IC50 values of 17.3 and 9.5 mu M, respectively.

引用

页码：9478 / 9482

页数：5

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