Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents

被引：40

作者：

Zheng, Qing-Zhong ^{[1
]}

Cheng, Kui ^{[1
]}

Zhang, Xiao-Min ^{[1
]}

Liu, Kai ^{[1
]}

Jiao, Qing-Cai ^{[1
]}

Zhu, Hai-Liang ^{[1
]}

机构：

[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 07期

基金：

美国国家科学基金会;

关键词：

Urea derivatives; Synthesis; Antibacterial; Antifungal; CARBONYLATION; ISOCYANATES; INHIBITORS; AMINES;

D O I：

10.1016/j.ejmech.2010.03.027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-alkyl substituted urea derivatives were synthesized and evaluated for their in vitro antibacterial and antifungal activities. The N-alkyl substituted urea derivatives bearing morpholine moiety (3a-3k) showed better activities than those bearing diethylamine moiety (2a-2f). Compounds having fluoro substituent at ortho (3c) and para (3b) positions of the phenyl ring exhibited potent antimicrobial activities against Gram-positive and Gram-negative bacteria as well as fungi. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：3207 / 3212

页数：6

共 50 条

[41] Synthesis of coumarin derivatives with cytotoxic, antibacterial and antifungal activity [J].

Khan, KM ;

Saify, ZS ;

Khan, MZ ;

Zia-Ullah ;

Choudhary, MI ;

Atta-ur-Rahman ;

Perveen, S ;

Chohan, ZH ;

Supuran, CT .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2004, 19 (04) :373-379

[42] Antibacterial, antifungal and cytotoxic evaluation of some new quinazolinone derivatives [J].

Hassanzadeh, F. ;

Jafari, E. ;

Hakimelahi, G. H. ;

Khajouei, M. Rahmani ;

Jalali, M. ;

Khodarahmi, G. A. .

RESEARCH IN PHARMACEUTICAL SCIENCES, 2012, 7 (02) :87-94

[43] Synthesis and biological evaluation of a new series of N-acyldiamines as potential antibacterial and antifungal agents [J].

Ferreira, Bianca da S. ;

de Almeida, Angelina M. ;

Nascimento, Thiago C. ;

de Castro, Pedro P. ;

Silva, Vania L. ;

Diniz, Claudio G. ;

Le Hyaric, Mireille .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (19) :4626-4629

[44] Synthesis and Antibacterial and Antifungal Activity of 5-Substituted Imidazolones [J].

Khan, Khalid Mohammed ;

Mughal, Uzma Rasool ;

Khan, Sadia ;

Khan, Saira ;

Perveen, Shahnaz ;

Choudhary, M. Iqbal .

LETTERS IN DRUG DESIGN & DISCOVERY, 2009, 6 (01) :69-77

[45] Synthesis, In Silico Study, Antibacterial and Antifungal Activities of N-phenylbenzamides [J].

Sulistyowaty, Melanny Ika ;

Putra, Galih Satrio ;

Budiati, Tutuk ;

Indrianingsih, Anastasia Wheni ;

Anwari, Farida ;

Kesuma, Dini ;

Matsunami, Katsuyoshi ;

Yamauchi, Takayasu .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (03)

[46] SYNTHESIS OF SOME HYDROXAMIC ACID-DERIVATIVES OF BENZIMIDAZOLE AND THEIR ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES [J].

GUNES, HS ;

COSAR, G .

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1992, 42-2 (08) :1045-1048

[47] Synthesis and Antibacterial Activity of N-Alkyl-Substituted 4-Aryldiazenylpyrazoles [J].

Ivanova, A. E. ;

Burgart, Ya. V. ;

Saloutin, V. I. .

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2013, 49 (08) :1128-1135

[48] Synthesis, Characterization, and Molecular Docking Study of Some Novel Imidazole Derivatives as Potential Antifungal Agents [J].

Isik, Aysen ;

Cevik, Ulviye Acar ;

Saglik, Beguem Nurpelin ;

Ozkay, Yusuf .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 56 (01) :142-152

[49] Synthesis of N-alkyl isatins via oxidative cyclization of N-alkyl 2-bromo(chloro)acetanilides [J].

Gui, Qingwen ;

Dai, Fenglin ;

Liu, Jidan ;

Chen, Peixing ;

Yang, Zhiyong ;

Chen, Xiang ;

Tan, Ze .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, 12 (21) :3349-3353

[50] Synthesis and Evaluation of 3-Halobenzo[b]thiophenes as Potential Antibacterial and Antifungal Agents [J].

Masih, Prerna J. ;

Kesharwani, Tanay ;

Rodriguez, Elivet ;

Vertudez, Mia A. ;

Motakhaveri, Mina L. ;

Le, Terelan K. ;

Tran, Minh Kieu T. ;

Cloyd, Matthew R. ;

Kornman, Cory T. ;

Phillips, Aimee M. .

PHARMACEUTICALS, 2022, 15 (01)

← 1 2 3 4 5 →