Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents

被引:40
作者
Zheng, Qing-Zhong [1 ]
Cheng, Kui [1 ]
Zhang, Xiao-Min [1 ]
Liu, Kai [1 ]
Jiao, Qing-Cai [1 ]
Zhu, Hai-Liang [1 ]
机构
[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China
基金
美国国家科学基金会;
关键词
Urea derivatives; Synthesis; Antibacterial; Antifungal; CARBONYLATION; ISOCYANATES; INHIBITORS; AMINES;
D O I
10.1016/j.ejmech.2010.03.027
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of N-alkyl substituted urea derivatives were synthesized and evaluated for their in vitro antibacterial and antifungal activities. The N-alkyl substituted urea derivatives bearing morpholine moiety (3a-3k) showed better activities than those bearing diethylamine moiety (2a-2f). Compounds having fluoro substituent at ortho (3c) and para (3b) positions of the phenyl ring exhibited potent antimicrobial activities against Gram-positive and Gram-negative bacteria as well as fungi. (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:3207 / 3212
页数:6
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