Education 4.0 is a model to meet the demands of Industry 4.0. This is achieved by developing competencies during the learning process that will later be used in Industry 4.0. The structural model proposed in this paper has four components: Cloud Computing infrastructures (applied in COVID-19 lockdown period), active hybrid methodologies (applicable in face-to-face, online, and blended learning mode), technologies (through a technological ecosystem), and horizontal 4.0 competences. These competencies have been acquired by integrating the active hybrid methodology with technologies. In the experience carried out, students have cooperatively used 4.0 competencies such as identifying, searching, evaluating, retrieving, creating, and using knowledge during the learning process. Likewise, the students have designed the technological system that classifies and manages all the knowledge created. Measured results show that the proposed Education 4.0 model has led to improvements in learning outcomes and has favoured peer-to-peer learning. The application of the 4.0 competencies has generated a 4.0 product which is the knowledge system to classify, organize, and use all the knowledge produced by the students through their learning experience in an academic subject.