Triggering antiviral response by RIG-I-related RNA helicases

被引：60
作者：
Fujita, Takashi [1 ]
Onoguchi, Kazuhide [1 ]
Onomoto, Koji [1 ]
Hirai, Reiko [1 ]
Yoneyama, Mitsutoshi [1 ]
机构：
[1] Kyoto Univ, Inst Virus Res, Mol Genet Lab, Kyoto 6068507, Japan
来源：
BIOCHIMIE | 2007年 / 89卷 / 6-7期
关键词：
interferon; RNA helicase; innate immunity; TLR; double-stranded RNA;
D O I：
10.1016/j.biochi.2007.01.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and dsRNA, and transduce signals leading to the production of IFN. Recently discovered cytoplasmic RNA helicases, RIG-I and MDA5, selectively sense viral RNA species. Gene disruption studies revealed the critical but non-redundant function of RIG-I and MDA5 in host antiviral responses. (C) 2007 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：754 / 760
页数：7
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