A bioactive polyacetylene compound isolated from Centella asiatica

被引：27

作者：

Govindan, G.

Sambandan, T. G.

Govindan, M.

Sinskey, A.

Vanessendelft, J.

Adenan, I.

Rha, C. K.

机构：

[1] MIT, Biomat Sci & Engn Lab, Cambridge, MA 02139 USA

[2] Fitchburg State Coll, Dept Chem, Fitchburg, MA USA

[3] MIT, Dept Biol, Cambridge, MA USA

[4] Forest Res Inst Malaysia, Kepong Selangor, Malaysia

来源：

PLANTA MEDICA | 2007年 / 73卷 / 06期

关键词：

D O I：

10.1055/s-2007-981521

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A polyacetylene compound was isolated from the aerial parts of Centella asiatica. The chemical structure of this new compound was identified as methyl 5-[(E)-9-hydroxy-1-(1-hydroxyhexyl)2-methoxyundeca-3,10-diene-5,7-diynyloxy]pentanoate (cadiyenol). This compound induces apoptosis (63%) independent of cell cycle regimen in mouse lymphoma cells (P388D1) at 28 mu M (IC50 = 24 +/- 2 pM) in 24 hours. The compound also reduces nitric oxide production by 70 +/- 2 % in lipopolysacharrideactivated mouse macrophages at 24 pM with no measurable cytotoxicity.

引用

页码：597 / 599

页数：3

共 9 条

[1]

Cheng CL, 2004, LIFE SCI, V74, P2237, DOI 10.1016/j.lfs.2003.09.055

[2] ANALYSIS OF NITRATE, NITRITE, AND [N-15]-LABELED NITRATE IN BIOLOGICAL-FLUIDS [J].