Synthesis and antitumor activity of new trans-1R,2R-diaminocyclohexaneplatinum(II) complexes containing disubstituted sulfide groups

被引：16
作者：
Shamsuddin, S [1 ]
AlBaker, S [1 ]
Siddik, ZH [1 ]
Khokhar, AR [1 ]
机构：
[1] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT CLIN INVEST,HOUSTON,TX 77030
来源：
INORGANICA CHIMICA ACTA | 1996年 / 241卷 / 02期
关键词：
platinum complexes; disubstituted sulfide complexes; diaminocyclohexane complexes; antitumour agents;
D O I：
10.1016/0020-1693(95)04735-2
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of cationic platinum(II) complexes of the form [Pt(DACH)(R'R''S)Cl]NO3, (where DACH = trans-1R,2R-diaminocyclohexane, and R'R''S = dimethylsulfide, diethylsulfide, dipropylsulfide, diisopropylsulfide, diphenylsulfide, dibenzylsulfide, thioanisole and methyl-p-tolylsulfide) have been synthesized and characterized by elemental analysis, IR, H-1 and Pt-195 NMR spectroscopic techniques. Some of these analogs were as active as cisplatin in the in vivo leukemia L1210/0 tumor model.
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页码：101 / 104
页数：4
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