Pediatric Acute Myeloid Leukemia Biology and Therapeutic Implications of Genomic Variants

被引：51

作者：

Tarlock, Katherine ^{[1
]}

Meshinchi, Soheil ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2015年 / 62卷 / 01期

关键词：

Acute myeloid leukemia; Pediatric; Epigenetic; Genomic; Therapy; INTERNAL TANDEM DUPLICATION; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; ACUTE MYELOGENOUS LEUKEMIA; HIGH-DOSE CYTARABINE; TRANS-RETINOIC ACID; ONCOLOGY-GROUP; PROGNOSTIC IMPLICATIONS; UNIPARENTAL DISOMY; RESIDUAL DISEASE;

D O I：

10.1016/j.pcl.2014.09.007

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Acute myeloid leukemia (AML) is a molecularly heterogeneous disease and age-associated molecular alterations result in younger children harboring a distinct signature from older children and adolescents. Pediatric AML has a genetic and epigenetic profile with significant differences compared to adult AML. Somatic and epigenetic alterations contribute to myeloid leukemogenesis and can evolve from diagnosis to relapse. Cytogenetic alterations, somatic mutations and response to induction therapy are important in informing risk stratification and appropriate therapy allocation. Next-generation sequencing technologies are providing novel insights into the biology of AML and have the ability to identify potential targets for therapeutic intervention.

引用

页码：75 / +

页数：20

共 68 条

[21] An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia [J].

Gruber, Tanja A. ;

Gedman, Amanda Larson ;

Zhang, Jinghui ;

Koss, Cary S. ;

Marada, Suresh ;

Ta, Huy Q. ;

Chen, Shann-Ching ;

Su, Xiaoping ;

Ogden, Stacey K. ;

Dang, Jinjun ;

Wu, Gang ;

Gupta, Vedant ;

Andersson, Anna K. ;

Pounds, Stanley ;

Shi, Lei ;

Easton, John ;

Barbato, Michael I. ;

Mulder, Heather L. ;

Manne, Jayanthi ;

Wang, Jianmin ;

Rusch, Michael ;

Ranade, Swati ;

Ganti, Ramapriya ;

Parker, Matthew ;

Ma, Jing ;

Radtke, Ina ;

Ding, Li ;

Cazzaniga, Giovanni ;

Biondi, Andrea ;

Kornblau, Steven M. ;

Ravandi, Farhad ;

Kantarjian, Hagop ;

Ninner, Stephen D. ;

Doehner, Konstanze ;

Doehner, Hartmut ;

Ley, Timothy J. ;

Ballerini, Paola ;

Shurtleff, Sheila ;

Tomizawa, Daisuke ;

Adachi, Souichi ;

Hayashi, Yasuhide ;

Tawa, Akio ;

Shih, Lee-Yung ;

Liang, Der-Cherng ;

Rubnitz, Jeffrey E. ;

Pui, Ching-Hon ;

Mardis, Elaine R. ;

Wilson, Richard K. ;

Downing, James R. .

CANCER CELL, 2012, 22 (05) :683-697

[22] Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia [J].

Gupta, Manu ;

Raghavan, Manoj ;

Gale, Rosemary E. ;

Chelala, Claude ;

Allen, Christopher ;

Molloy, Gael ;

Chaplin, Tracy ;

Linch, David C. ;

Cazier, Jean-Baptiste ;

Young, Bryan D. .

GENES CHROMOSOMES & CANCER, 2008, 47 (09) :729-739

[23] Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study [J].

Hasle, Henrik ;

Alonzo, Todd A. ;

Auvrignon, Anne ;

Behar, Catherine ;

Chang, Myron ;

Creutzig, Ursula ;

Fischer, Alexandra ;

Forestier, Erik ;

Fynn, Alcira ;

Haas, Oskar A. ;

Harbott, Jochen ;

Harrison, Christine J. ;

Heerema, Nyla A. ;

van den Heuvel-Eibrink, Marry M. ;

Kaspers, Gertjan J. L. ;

Locatelli, Franco ;

Noellke, Peter ;

Polychronopoulou, Sophia ;

Ravindranath, Yaddanapudi ;

Razzouk, Bassem ;

Reinhardt, Dirk ;

Savva, Natalia N. ;

Stark, Batia ;

Suciu, Stefan ;

Tsukimoto, Ichiro ;

Webb, David K. ;

Wojcik, Dorora ;

Woods, William G. ;

Zimmermann, Martin ;

Niemeyer, Charlotte M. ;

Raimondi, Susana C. .

BLOOD, 2007, 109 (11) :4641-4647

[24]

Helton HL, 2012, ASH ANN M, V120, P125

[25] Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study [J].

Ho, P. A. ;

Alonzo, T. A. ;

Kopecky, K. J. ;

Miller, K. L. ;

Kuhn, J. ;

Zeng, R. ;

Gerbing, R. B. ;

Raimondi, S. C. ;

Hirsch, B. A. ;

Oehler, V. ;

Hurwitz, C. A. ;

Franklin, J. L. ;

Gamis, A. S. ;

Petersdorf, S. H. ;

Anderson, J. E. ;

Reaman, G. H. ;

Baker, L. H. ;

Willman, C. L. ;

Bernstein, I. D. ;

Radich, J. P. ;

Appelbaum, F. R. ;

Stirewalt, D. L. ;

Meshinchi, S. .

LEUKEMIA, 2010, 24 (05) :909-913

[26] Leukemic Mutations in the Methylation-Associated Genes DNMT3A and IDH2 Are Rare Events in Pediatric AML: A Report From the Children's Oncology Group [J].

Ho, Phoenix A. ;

Kutny, Matthew A. ;

Alonzo, Todd A. ;

Gerbing, Robert B. ;

Joaquin, Jason ;

Raimondi, Susana C. ;

Gamis, Alan S. ;

Meshinchi, Soheil .

PEDIATRIC BLOOD & CANCER, 2011, 57 (02) :204-209

[27] Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group [J].

Ho, Phoenix A. ;

Zeng, Rong ;

Alonzo, Todd A. ;

Gerbing, Robert B. ;

Miller, Kristen L. ;

Pollard, Jessica A. ;

Stirewalt, Derek L. ;

Heerema, Nyla A. ;

Raimondi, Susana C. ;

Hirsch, Betsy ;

Franklin, Janet L. ;

Lange, Beverly ;

Meshinchi, Soheil .

BLOOD, 2010, 116 (05) :702-710

[28] Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group [J].

Ho, Phoenix A. ;

Alonzo, Todd A. ;

Gerbing, Robert B. ;

Pollard, Jessica ;

Stirewalt, Derek L. ;

Hurwitz, Craig ;

Heerema, Nyla A. ;

Hirsch, Betsy ;

Raimondi, Susana C. ;

Lange, Beverly ;

Franklin, Janet L. ;

Radich, Jerald P. ;

Meshinchi, Soheil .

BLOOD, 2009, 113 (26) :6558-6566

[29]

Hollink IH, 2007, ASH ANN MEET ABSTR, V110, P366

[30] Impact of Disease Risk on Efficacy of Matched Related Bone Marrow Transplantation for Pediatric Acute Myeloid Leukemia: The Children's Oncology Group [J].

Horan, John T. ;

Alonzo, Todd A. ;

Lyman, Gary H. ;

Gerbing, Robert B. ;

Lange, Beverly J. ;

Ravindranath, Yaddanapudi ;

Becton, David ;

Smith, Franklin O. ;

Woods, William G. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (35) :5797-5801

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