B cells require "nurturing" by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus

被引：10

作者：

Choudhury, Arpita ^{[1
]}

Cohen, Philip L. ^{[2
]}

Eisenberg, Robert A. ^{[1
]}

机构：

[1] Univ Penn, Div Rheumatol, Philadelphia, PA 19104 USA

[2] Temple Univ, Sch Med, Rheumatol Sect, Philadelphia, PA 19140 USA

来源：

CLINICAL IMMUNOLOGY | 2010年 / 136卷 / 01期

关键词：

Graft-versus-host disease; B cells; T cells; Systemic lupus erythematosus; Autoantibodies; HEAT-STABLE ANTIGEN(HI); IFN-GAMMA; AUTOANTIBODY PRODUCTION; IN-VIVO; LIGAND DYSREGULATION; AUTOIMMUNE SYNDROME; HIV-INFECTION; IL-4; PROMOTES; HELPER CELLS; DISEASE;

D O I：

10.1016/j.clim.2010.03.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The murine chronic GVH (cGVH) model of SLE is induced by alto-recognition of foreign major histocompatibility complex (MHC) class II determinants. Previous studies have shown that syngeneic CD4(+) T cells are needed during B cell development in order to induce cGVH response in CD4KO mice. Our present studies show that B cells require "nurturing" by CD4 T cells through much of their ontogeny in order to respond to allo-signaling and become autoreactive. The nurturing process does not require antigen-specific cognate interactions between CD4 T cells and B cells. It is mediated by IL-4, but not IL-10, IL-6 and IFN-gamma. The CD4 T cell nurturing may be supplanted by large doses of IL-4 and/or by agonistic anti-CD40 mAb. Understanding the mechanism of this "nurturing" process may yield clues to the role of CD4 T cells in lupus and in host defense in general. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：105 / 115

页数：11

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