Anti-inflammatory effect and modulation of cytochrome P450 activities by Artemisia annua tea infusions in human intestinal Caco-2 cells

被引：68
|
作者：
de Magalhaes, Pedro Melillo [1 ,2 ,3 ]
Dupont, Isabelle [1 ,2 ]
Hendrickx, Aurelie [1 ,2 ]
Joly, Aurelie [1 ,2 ]
Raas, Thomas [1 ,2 ]
Dessy, Stephanie [4 ]
Sergent, Therese [1 ,2 ]
Schneider, Yves-Jacques [1 ,2 ]
机构：
[1] Inst Sci Vie, B-1348 Louvain, Belgium
[2] UCLouvain, B-1348 Louvain, Belgium
[3] Univ Estadual Campinas, CPQBA, BR-13140000 Paulinia, SP, Brazil
[4] Celabor Scrl, B-4650 Chaineux, Belgium
来源：
FOOD CHEMISTRY | 2012年 / 134卷 / 02期
关键词：
Artemisia annua; Artemisinin; Caco-2; cells; CYPs; Intestinal inflammation; Phenolic compounds; Rosmarinic acid; ROSMARINIC ACID; PHENOLIC-COMPOUNDS; METABOLISM; L; INHIBITION; FLAVONOIDS; EXTRACTS; POLYPHENOLS; ABSORPTION; QINGHAOSU;
D O I：
10.1016/j.foodchem.2012.02.195
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In an attempt to understand the beneficial health effects of Artemisia annua other than its anti-malaria properties, extracts from different cultivars prepared as tea infusions were investigated using Caco-2 cells on the intestinal inflammation and cytochrome P450 (CYP) activities. The characterisation of their phenolic compound (PC) profile revealed rosmarinic and chlorogenic acids as the main PCs. The extracts, assayed on Caco-2 cells at a plausible intestinal concentration, significantly decreased the secretion of pro-inflammatory cytokines, IL-8 and IL-6. This effect could be attributable at least to their content in rosmarinic acid, detected as a potent anti-inflammatory compound. The extracts also inhibited the activity of CYP3A4, whose expression was induced by 1,25-dihydroxyvitamin D-3, and of CYP1A1, induced by benzo(a)pyrene. Our results highlight the advantage of drinking A. annua infusions for their potent anti-inflammatory effect, linked to PC content, which could synergise their antimalarial activity. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：864 / 871
页数：8
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