Snail More than EMT

被引：208
作者：
Wu, Yadi [2 ,3 ]
Zhou, Binhua P. [1 ,3 ]
机构：
[1] Univ Kentucky, Sch Med, Dept Mol & Cellular Biochem, Lexington, KY 40536 USA
[2] Univ Kentucky, Sch Med, Dept Mol & Biomed Pharmacol, Lexington, KY 40536 USA
[3] Univ Kentucky, Sch Med, Markey Canc Ctr, Lexington, KY 40536 USA
来源：
CELL ADHESION & MIGRATION | 2010年 / 4卷 / 02期
关键词：
Snail; EMT; stem cell; apoptosis; immunosuppression;
D O I：
10.4161/cam.4.2.10943
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Snail has moved into the fast lane of development and cancer biology with the epithelial-mesenchymal transition (EMT) emerging as one of the hottest topics in medical science within the past few years. Snail not only acts primarily as a key inducer of EMT but also plays an important role in cell survival, immune regulation and stem cell biology. This review focuses on the regulation of Snail and discusses the EMT-dependent and -independent functions of Snail in development and disease. Understanding the regulation and functional roles of Snail will shed new light on the mechanism of tumor progression and the development of novel cancer therapies.
引用
收藏
页码：199 / 203
页数：5
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