Evidence that endogenous neurotensin exerts a tonic inhibitory influence on adrenal zona glomerulosa growth and secretory activity in the rat

被引：0
|
作者：
Malendowicz, LK
Nussdorfer, GG
Hinson, JP
Vinson, GP
机构：
[1] UNIV PADUA,DEPT ANAT,I-35121 PADUA,ITALY
[2] SCH MED,DEPT HISTOL & EMBRYOL,PL-60781 POZNAN,POLAND
[3] UNIV LONDON QUEEN MARY & WESTFIELD COLL,FAC BASIC MED SCI,DEPT BIOCHEM,LONDON E1 4NS,ENGLAND
来源：
MEDICAL SCIENCE RESEARCH | 1996年 / 24卷 / 03期
关键词：
neurotensin; zona glomerulosa; adrenal cortex; adrenocorticotropic hormone; steroidogenesis;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
To assess the role of endogenous neurotensin (NT) in the regulation of adrenocortical function, adult rats were given [D-Trp(11)]-NT, a specific NT-receptor antagonist (NT-A), subcutaneously, 4 nmol day(-1) for 7 days. NT-A raised the concentration of aldosterone in circulating blood, without affecting ACTH or corticosterone, and induced a marked hypertrophy of the zona glomerulosa. These effects of NT-A were reversed by the simultaneous administration of equimolar doses of NT. These results suggest that endogenous NT exerts a specific tonic inhibitory influence on the zona glomerulosa in rats.
引用
收藏
页码：189 / 190
页数：2
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