Preparation of Chiral Multifunctional Thiourea-Phosphanes and Synthesis of Chiral Allylic Phosphites and Phosphane Oxides through Asymmetric Allylic Substitution Reactions of Morita-Baylis-Hillman Carbonates

被引：54
作者：
Deng, Hong-Ping [1 ]
Shi, Min [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Organocatalysis; Asymmetric catalysis; Allylic compounds; Amines; N-SULFONATED IMINES; METHYL VINYL KETONE; HILIMAN REACTION; ALPHA-AMINO; ENANTIOSELECTIVE CONSTRUCTION; BIFUNCTIONAL ORGANOCATALYSTS; GAMMA-BUTENOLIDES; BASE; ACID; PHOSPHINOTHIOUREA;
D O I：
10.1002/ejoc.201101365
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We developed a synthetic method to prepare chiral multifunctional thiourea-phosphane catalysts for the asymmetric allylic substitution reaction of Morita-Baylis-Hillman carbonates with diphenyl phosphite or diphenylphosphane oxide to give allylic phosphites and allylic phosphane oxides in high yields with excellent enantioselectivity.
引用
收藏
页码：183 / 187
页数：5
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