Preparation of Chiral Multifunctional Thiourea-Phosphanes and Synthesis of Chiral Allylic Phosphites and Phosphane Oxides through Asymmetric Allylic Substitution Reactions of Morita-Baylis-Hillman Carbonates

被引：55

作者：

Deng, Hong-Ping ^{[1
]}

Shi, Min ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Organocatalysis; Asymmetric catalysis; Allylic compounds; Amines; N-SULFONATED IMINES; METHYL VINYL KETONE; HILIMAN REACTION; ALPHA-AMINO; ENANTIOSELECTIVE CONSTRUCTION; BIFUNCTIONAL ORGANOCATALYSTS; GAMMA-BUTENOLIDES; BASE; ACID; PHOSPHINOTHIOUREA;

D O I：

10.1002/ejoc.201101365

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We developed a synthetic method to prepare chiral multifunctional thiourea-phosphane catalysts for the asymmetric allylic substitution reaction of Morita-Baylis-Hillman carbonates with diphenyl phosphite or diphenylphosphane oxide to give allylic phosphites and allylic phosphane oxides in high yields with excellent enantioselectivity.

引用

页码：183 / 187

页数：5

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