Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl)indole and 1-pentyl-3-(1-adamantoyl)indole in seized bulk powders in Hungary

被引：63

作者：

Jankovics, Peter ^{[1
]}

Varadi, Andras ^{[2
]}

Toelgyesi, Laszlo ^{[3
,4
]}

Lohner, Szilvia ^{[1
]}

Nemeth-Palotas, Julia ^{[1
]}

Balla, Jozsef ^{[5
]}

机构：

[1] Natl Inst Pharm, H-1051 Budapest, Hungary

[2] Semmelweis Univ, Dept Pharmaceut Chem, H-1092 Budapest, Hungary

[3] Eotvos Lorand Univ, Joint Res & Training Lab Separat Tech, H-1117 Budapest, Hungary

[4] Kromat Ltd Co, H-1112 Budapest, Hungary

[5] Budapest Univ Technol & Econ, Dept Inorgan & Analyt Chem, H-1111 Budapest, Hungary

来源：

FORENSIC SCIENCE INTERNATIONAL | 2012年 / 214卷 / 1-3期

关键词：

1-Pentyl-3-(2-iodobenzoyl)indole; 1-Pentyl-3-(1-adamantoyl)indole; Cannabimimetic; LC-MS; GC-MS; NMR; CANNABIMIMETIC INDOLES; CB2; RECEPTOR; PYRROLES; INDENES;

D O I：

10.1016/j.forsciint.2011.07.011

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

3-Naphthoyl- and 3-phenylacetylindoles represent a group of substances of cannabimimetic activity with affinities - strongly influenced by their functional groups - to cannabinoid receptors CB1 and CB2. Some of them have been described as ingredients of herbal blends also known as "smart products'' by several research groups. Recently further cannabimimetic substances possessing new chemical structures like benzoylindoles and adamantoylindoles have emerged. In Hungary, two powder samples were seized by the authorities and identified as 1-pentyl-3-(2-iodobenzoyl)indole (AM-679) and 1-pentyl- 3-(1-adamantoyl)indole. Structure elucidation was carried out by LC-UV-MS/MS, LC-TOF-MS, GC-MS and NMR. The benzoylindole AM-679 is a known agonist of cannabinoid receptors while the adamantoylindole derivative also carries chemical features typical for cannabimimetics. It is thus assumed that both substances might be detected in "smart products'' in the future. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：27 / 32

页数：6

共 20 条

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