Optimizing Immunomodulatory Drug With Proteasome Inhibitor Combinations in Newly Diagnosed Multiple Myeloma

被引：14

作者：

Ntanasis-Stathopoulos, Ioannis ^{[1
]}

Terpos, Evangelos ^{[1
]}

Dimopoulos, Meletios A. ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Alexandra Gen Hosp, Dept Clin Therapeut, Athens, Greece

来源：

CANCER JOURNAL | 2019年 / 25卷 / 01期

关键词：

immunomodulatory agents; multiple myeloma; NDMM; proteasome inhibitor; STEM-CELL TRANSPLANTATION; BORTEZOMIB-THALIDOMIDE-DEXAMETHASONE; LOW-DOSE DEXAMETHASONE; INDUCTION THERAPY; CONSOLIDATION THERAPY; MAINTENANCE THERAPY; PHASE-II; AUTOLOGOUS TRANSPLANTATION; LENALIDOMIDE-DEXAMETHASONE; LIPOSOMAL DOXORUBICIN;

D O I：

10.1097/PPO.0000000000000348

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the modern era of multiple myeloma therapeutics, proteasome inhibitor (PI) and immunomodulatory drugs (IMiDs) have replaced chemotherapy regimens for newly diagnosed multiple myeloma patients. Treatment combinations that comprise both first- and next-generation PIs, including bortezomib, carfilzomib, and ixazomib and IMiDs, including thalidomide and lenalidomide, have been evaluated in phases II and III clinical trials and have shown significant efficacy with manageable toxicity profiles. Bortezomib or carfilzomib with lenalidomide and dexamethasone (VRD and KRD) are the most promising regimens resulting in significant survival improvement. Disease and patient characteristics should lead the individualization of treatment, with the eligibility for autologous transplant being of principal importance. The addition of a monoclonal antibody to PI with IMiD combinations is currently under clinical investigation and may lead to further treatment optimization.

引用

页码：2 / 10

页数：9

共 73 条

[11]

Canioni D, 2017, BLOOD, V130

[12] Bortezomib-thalidomide-dexamethasone is superior to thalidomide-dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma [J].

Cavo, Michele ;

Pantani, Lucia ;

Petrucci, Maria Teresa ;

Patriarca, Francesca ;

Zamagni, Elena ;

Donnarumma, Daniela ;

Crippa, Claudia ;

Boccadoro, Mario ;

Perrone, Giulia ;

Falcone, Antonietta ;

Nozzoli, Chiara ;

Zambello, Renato ;

Masini, Luciano ;

Furlan, Anna ;

Brioli, Annamaria ;

Derudas, Daniele ;

Ballanti, Stelvio ;

Dessanti, Maria Laura ;

De Stefano, Valerio ;

Carella, Angelo Michele ;

Marcatti, Magda ;

Nozza, Andrea ;

Ferrara, Felicetto ;

Callea, Vincenzo ;

Califano, Catello ;

Pezzi, Annalisa ;

Baraldi, Anna ;

Grasso, Mariella ;

Musto, Pellegrino ;

Palumbo, Antonio .

BLOOD, 2012, 120 (01) :9-19

[13] Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study [J].

Cavo, Michele ;

Tacchetti, Paola ;

Patriarca, Francesca ;

Petrucci, Maria Teresa ;

Pantani, Lucia ;

Galli, Monica ;

Di Raimondo, Francesco ;

Crippa, Claudia ;

Zamagni, Elena ;

Palumbo, Antonio ;

Offidani, Massimo ;

Corradini, Paolo ;

Narni, Franco ;

Spadano, Antonio ;

Pescosta, Norbert ;

Deliliers, Giorgio Lambertenghi ;

Ledda, Antonio ;

Cellini, Claudia ;

Caravita, Tommaso ;

Tosi, Patrizia ;

Baccarani, Michele .

LANCET, 2010, 376 (9758) :2075-2085

[14] Maintenance in myeloma patients achieving complete response after upfront therapy: a pooled analysis [J].

Cerrato, Chiara ;

Di Raimondo, Francesco ;

De Paoli, Lorenzo ;

Spada, Stefano ;

Patriarca, Francesca ;

Crippa, Claudia ;

Mina, Roberto ;

Guglielmelli, Tommasina ;

Ben-Yehuda, Dina ;

Oddolo, Daniela ;

Nozzoli, Chiara ;

Angelucci, Emanuele ;

Cascavilla, Nicola ;

Rizzi, Rita ;

Rocco, Stefano ;

Baldini, Luca ;

Ponticelli, Elena ;

Marcatti, Magda ;

Cangialosi, Clotilde ;

Caravita, Tommaso ;

Benevolo, Giulia ;

Ria, Roberto ;

Nagler, Arnon ;

Musto, Pellegrino ;

Tacchetti, Paola ;

Corradini, Paolo ;

Offidani, Massimo ;

Palumbo, Antonio ;

Petrucci, Maria Teresa ;

Boccadoro, Mario ;

Gay, Francesca .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2018, 144 (07) :1357-1366

[15] Outcomes of maintenance therapy with lenalidomide or bortezomib in multiple myeloma in the setting of early autologous stem cell transplantation [J].

Chakraborty, R. ;

Muchtar, E. ;

Kumar, S. K. ;

Buadi, F. K. ;

Dingli, D. ;

Dispenzieri, A. ;

Hayman, S. R. ;

Hogan, W. J. ;

Kapoor, P. ;

Lacy, M. Q. ;

Leung, N. ;

Warsame, R. ;

Kourelis, T. ;

Gonsalves, W. ;

Gertz, M. A. .

LEUKEMIA, 2018, 32 (03) :712-718

[16] The impact of induction regimen on transplant outcome in newly diagnosed multiple myeloma in the era of novel agents [J].

Chakraborty, R. ;

Muchtar, E. ;

Kumar, S. ;

Buadi, F. K. ;

Dingli, D. ;

Dispenzieri, A. ;

Hayman, S. R. ;

Hogan, W. J. ;

Kapoor, P. ;

Lacy, M. Q. ;

Leung, N. ;

Gertz, M. A. .

BONE MARROW TRANSPLANTATION, 2017, 52 (01) :34-40

[17] Importance of Achieving a Complete Response in Multiple Myeloma, and the Impact of Novel Agents [J].

Chanan-Khan, Asher A. ;

Giralt, Sergio .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15) :2612-2624

[18] Maintenance versus Induction Therapy Choice on Outcomes after Autologous Transplantation for Multiple Myeloma [J].

Cornell, Robert F. ;

D'Souza, Anita ;

Kassim, Adetola A. ;

Costa, Luciano J. ;

Innis-Shelton, Racquel D. ;

Zhang, Mei-Jie ;

Huang, Jiaxing ;

Abidi, Muneer ;

Aiello, Jack ;

Akpek, Gorgun ;

Bashey, Asad ;

Bashir, Qaiser ;

Cerny, Jan ;

Comenzo, Raymond ;

Angel Diaz, Miguel ;

Freytes, Cesar ;

Gale, Robert Peter ;

Ganguly, Siddhartha ;

Hamadani, Mehdi ;

Hashmi, Shahrukh ;

Holmberg, Leona ;

Hossain, Nasheed ;

Kamble, Rammurti T. ;

Kharfan-Dabaja, Mohamed ;

Kindwall-Keller, Tamila ;

Kyle, Robert ;

Kumar, Shaji ;

Lazarus, Hillard ;

Lee, Cindy ;

Maiolino, Angelo ;

Marks, David I. ;

Meehan, Kenneth ;

Mikhael, Joe ;

Nath, Rajneesh ;

Nishihori, Taiga ;

Olsson, Richard F. ;

Ramanathan, Muthalagu ;

Saad, Ayman ;

Seo, Sachiko ;

Usmani, Saad ;

Vesole, David ;

Vij, Ravi ;

Vogl, Dan ;

Wirk, Baldeep M. ;

Yared, Jean ;

Krishnan, Amrita ;

Mark, Tomer ;

Nieto, Yago ;

Hari, Parameswaran .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2017, 23 (02) :269-277

[19] Global Burden of Multiple Myeloma ASystematic Analysis for the Global Burden of Disease Study 2016 [J].

Cowan, Andrew J. ;

Allen, Christine ;

Barac, Aleksandra ;

Basaleem, Huda ;

Bensenor, Isabela ;

Curado, Maria Paula ;

Foreman, Kyle ;

Gupta, Rahul ;

Harvey, James ;

Hosgood, H. Dean ;

Jakovljevic, Mihajlo ;

Khader, Yousef ;

Linn, Shai ;

Lad, Deepesh ;

Mantovani, Lorenzo ;

Vuong Minh Nong ;

Mokdad, Ali ;

Naghavi, Mohsen ;

Postma, Maarten ;

Roshandel, Gholamreza ;

Shackelford, Katya ;

Sisay, Mekonnen ;

Cuong Tat Nguyen ;

Tung Thanh Tran ;

Bach Tran Xuan ;

Ukwaja, Kingsley Nnanna ;

Vollset, Stein Emil ;

Weiderpass, Elisabete ;

Libby, Edward N. ;

Fitzmaurice, Christina .

JAMA ONCOLOGY, 2018, 4 (09) :1221-1227

[20] Autologous Transplantation for Newly Diagnosed Multiple Myeloma in the Era of Novel Agent Induction A Systematic Review and Meta-analysis [J].

Dhakal, Binod ;

Szabo, Aniko ;

Chhabra, Saurabh ;

Hamadani, Mehdi ;

D'Souza, Anita ;

Usmani, Saad Z. ;

Sieracki, Rita ;

Gyawali, Bishal ;

Jackson, Jeffrey L. ;

Asimakopoulos, Fotis ;

Hari, Parameswaran N. .

JAMA ONCOLOGY, 2018, 4 (03) :343-350

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