Enantioselective hydrogenation of allylphthalimides:: An efficient method for the synthesis of β-methyl chiral amines

被引：44

作者：

Wang, CJ ^{[1
]}

Sun, XF ^{[1
]}

Zhang, XM ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 31期

关键词：

amines; asymmetric catalysis; enantioselectivity; hydrogenation; ruthenium;

D O I：

10.1002/anie.200501332

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) High yields and up to 98% ee have been achieved by asymmetric hydrogenation of allylphthalimides followed by hydrolysis to give β-methyl chiral amines by using a Ru-C3-tunephos catalyst (see scheme). The synthetic utility of this procedure has been demonstrated through the synthesis of the key intermediate of the LTs receptor antagonist (Zeneca ZD 3532). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4933 / 4935

页数：3

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