Early Detection of Ovarian Cancer

被引：137

作者：

Elias, Kevin M. ^{[1
]}

Guo, Jing ^{[2
,3
]}

Bast, Robert C., Jr. ^{[2
]}

机构：

[1] Harvard Med Sch, Dana Farber Canc Inst, Brigham & Womens Hosp, Div Gynecol Oncol,Dept Obstet & Gynecol, 75 Francis St, Boston, MA 02115 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, 1515 Holcombe Blvd, Houston, TX 77030 USA

[3] Tongji Univ, Shanghai Peoples Hosp 10, Dept Gynecol & Obstet, 301 Yanchang Rd, Shanghai 200072, Peoples R China

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2018年 / 32卷 / 06期

关键词：

Ovarian cancer; Early detection; Screening; CA125; miRNA; TP53; Autoantibodies; ctDNA; METHYLATION-SPECIFIC PCR; SOMATIC TP53 MUTATIONS; UK COLLABORATIVE TRIAL; CELL-FREE DNA; PERITONEAL-FLUID; SCREENING TRIAL; ALGORITHM ROCA; TUMOR DNA; BREAST; BLOOD;

D O I：

10.1016/j.hoc.2018.07.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Early detection of ovarian cancer could reduce mortality by 10% to 30%. Effective screening requires high sensitivity (>75%) and extremely high specificity (99.7%). Clinical trials suggest the best specificity is achieved with 2-stage strategies in which increasing serum CA125 level triggers transvaginal sonography to detect a malignant pelvic mass, although evidence for such approaches improving overall survival has been limited. Screening may be improved by combining CA125 with novel biomarkers, such as autoantibodies, circulating tumor DNA, or microRNAs. In order to detect premetastatic ovarian cancers originating in the distal fallopian tube, more sensitive approaches to diagnostic imaging are required.

引用

页码：903 / +

页数：13

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