Spectrofluorimetric Assessment of Doxycycline Hydrochloride in Pharmaceutical Tablets and Serum Sample Based on the Enhancement of the Luminescence Intensity of the Optical Sensor Sm3+ Ion

被引：41

作者：

Attia, M. S. ^{[1
]}

Mahmoud, W. H. ^{[3
]}

Ramsis, M. N. ^{[1
]}

Khalil, L. H. ^{[1
]}

Othman, A. M. ^{[2
]}

Hashem, S. G. ^{[1
]}

Mostafa, S. ^{[1
]}

机构：

[1] Ain Shams Univ, Fac Sci, Dept Chem, Cairo, Egypt

[2] Minofiea Univ, Genet Engn & Biotechnol Res Inst GEBRI, Dept Environm Biotechnol, Sadat City, Egypt

[3] Taibah Univ, Fac Sci Appl, Dept Chem, Al Madinah, Al Munawarah, Saudi Arabia

来源：

JOURNAL OF FLUORESCENCE | 2011年 / 21卷 / 04期

关键词：

Doxycycline; Sm3+- doxycycline complex; Optical sensor; Luminescence intensity; LIQUID-CHROMATOGRAPHIC METHOD; ACIDIC MOBILE PHASES; TETRACYCLINE ANTIBIOTICS; SPECTROPHOTOMETRIC DETERMINATION; SENSITIZED LUMINESCENCE; POLYMERIC COLUMNS; OXYTETRACYCLINE; FLUORESCENCE; VALIDATION; ELECTRODES;

D O I：

10.1007/s10895-011-0869-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple and sensitive spectrofluorimetric method for determination of trace amount of doxycycline hydrochloride (DC) in pharmaceutical tablets and serum samples was developed. In ammonia buffer solution of pH 8.9 the doxycycline hydrochloride can remarkably enhance the luminescence intensity of the Sm3+ ion in Sm3+- DC complex at lambda(ex) = 400 nm. The produced luminescence intensity of Sm3+- DC complex in DMSO is in proportion to the concentration of DC and used as optical sensor for its determination. The dynamic range for the determination of DC is 1 x 10(-8) - 5 x 10(-6) mol L-1 and in case of quantum yield calculations is 7 x 10(-9) - 5 x 10(-6) mol L-1 with detection limit of 6.5 x 10(-10) mol L-1. The enhancement mechanism of the luminescence intensity in the Sm3+- DC system has been also discussed. A comparison with other spectrofluorimetric methods for tetracycline derivatives in which Eu3+ ion is used instead of Sm3+ ion is also studied.

引用

页码：1739 / 1748

页数：10

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