Effects of subchronic digestive exposure to organic or inorganic cadmium on biomarkers in rat tissues

被引：13

作者：

Hispard, F. ^{[1
]}

de Vaufleury, A. ^{[1
]}

Martin, H. ^{[2
]}

Devaux, S. ^{[2
]}

Cosson, R. P. ^{[3
]}

Scheifler, R. ^{[1
]}

Richert, L. ^{[2
]}

Berthelot, A. ^{[2
]}

Badot, P. -M. ^{[1
]}

机构：

[1] Univ Franche Comte, Dept Environm Biol, INRA, EA 3184, F-25030 Besancon, France

[2] Univ Franche Comte, EA 3921, F-25030 Besancon, France

[3] Univ Nantes, Marine Biol Lab, ISOMer UPRES EA 2663, F-44322 Nantes, France

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2008年 / 70卷 / 03期

关键词：

food chain; cadmium form; metallothionein; antioxidant status; caspase; 3; aminotransferases;

D O I：

10.1016/j.ecoenv.2007.04.005

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In an experimental food chain, Wistar rats were fed cadmium (Cd) in an inorganic (CdCl2) or organic (mainly associated with metallothionein from Helix aspersa snail viscera) form. After 1 month of exposure to 100 mu g inorganic Cd g(-1) in food, an induction of metallothionein was observed in all target tissues. In liver, glutathione peroxidase (GSH-Px) activity decreased and alanine aminotransferase (ALAT) activity increased, suggesting that Cd causes hepatotoxicity. However, lipid peroxidation as well as catalase and caspase 3 (a marker of apoptosis) activities were not modified. At a rather low exposure (2.5 mu g Cd g(-1)), metallothionein level in the kidney was found to be the most sensitive biomarker of exposure for both Cd forms. In the small intestine of rats ingesting inorganic Cd, metallothionein expression was significantly higher than that observed for rats fed organic Cd. Present results allowed proposing a simple design to assess the effect of a chemical in a trophic transfer approach. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：490 / 498

页数：9

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