Recent advances in Schistosoma genomics

被引:15
作者
Mourao, M. M. [1 ]
Grunau, C. [2 ]
LoVerde, P. T. [3 ,4 ]
Jones, M. K. [5 ]
Oliveira, G. [1 ]
机构
[1] Fundacao Oswaldo Cruz FIOCRUZ, Ctr Pesquisas Rene Rachou, Inst Nacl Ciencia & Tecnol Doencas Tropicais, Genom & Computat Biol Grp, BR-30190002 Belo Horizonte, MG, Brazil
[2] Univ Perpignan, UMR CNRS 5244, Lab Ecol & Evolut Interact 2EI, F-66025 Perpignan, France
[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA
[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA
[5] Univ Queensland, Queensland Inst Med Res, Sch Vet Sci, Herston, Qld, Australia
关键词
disease; epigenetics; functional genomics; genomics; parasite; Schistosoma spp; schistosomiasis; GENE-EXPRESSION; BLOOD FLUKE; MOLECULAR CHARACTERIZATION; EPIGENETIC INHERITANCE; TRANSCRIPTOME ANALYSIS; HISTONE DEACETYLASES; PROTEOMIC ANALYSIS; RNA INTERFERENCE; DNA METHYLATION; MANSONI;
D O I
10.1111/j.1365-3024.2011.01349.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Schistosome research has entered the genomic era with the publications reporting the Schistosoma mansoni and Schistosoma japonicum genomes. Schistosome genomics is motivated by the need for new control tools. However, much can also be learned about the biology of Schistosoma, which is a tractable experimental model. In this article, we review the recent achievements in the field of schistosome research and discuss future perspectives on genomics and how it can be integrated in a usable format, on the genetic mapping and how it has improved the genome assembly and provided new research approaches, on how epigenetics provides interesting insights into the biology of the species and on new functional genomics tools that will contribute to the understanding of the function of genes, many of which are parasite- or taxon specific.
引用
收藏
页码:151 / 162
页数:12
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