3D modeling of noncontact fiber based approach for time-resolved Diffuse Optical Tomography

We developed a time-resolved diffuse optical tomography system that enables performing noncontact 3D-DOT measurements of irregular shapes which is appropriate for small animal imaging. To retrieve the surface mesh, a noncontact holographic setup using a sensor and an XY optical scanning system was used. We present a noncontact modeling approach that consists in computing the temporal intensity distribution of detected photons taking into account the free space propagation from, and to, the fibers disposed around the studied object at some distance from its surface. The optimization was performed once on the time-weighted moments then on some points of the temporal profiles.