Immunometabolism of Myeloid-Derived Suppressor Cells: Implications for Mycobacterium tuberculosis Infection and Insights from Tumor Biology

被引:5
作者
Munansangu, Brian S. M. [1 ]
Kenyon, Colin [1 ]
Walzl, Gerhard [1 ]
Loxton, Andre G. [1 ]
Kotze, Leigh A. [1 ]
du Plessis, Nelita [1 ]
机构
[1] Stellenbosch Univ, Fac Med & Hlth Sci, DSI NRF Ctr Excellence Biomed TB Res,Fac Med & Hl, South African Med Res Council Ctr TB Res,Div Mol, ZA-7505 Cape Town, South Africa
基金
新加坡国家研究基金会;
关键词
MDSC; tuberculosis; metabolic reprogramming; glycolysis; OXPHOS; immunometabolism; ENHANCES IMMUNE SUPPRESSION; T-CELL; REACTIVE OXYGEN; ALVEOLAR MACROPHAGES; CANCER STAGE; NEUTROPHILS; METABOLISM; MECHANISM; DIFFERENTIATION; HETEROGENEITY;
D O I
10.3390/ijms23073512
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The field of immunometabolism seeks to decipher the complex interplay between the immune system and the associated metabolic pathways. The role of small molecules that can target specific metabolic pathways and subsequently alter the immune landscape provides a desirable platform for new therapeutic interventions. Immunotherapeutic targeting of suppressive cell populations, such as myeloid-derived suppressor cells (MDSC), by small molecules has shown promise in pathologies such as cancer and support testing of similar host-directed therapeutic approaches in MDSC-inducing conditions such as tuberculosis (TB). MDSC exhibit a remarkable ability to suppress T-cell responses in those with TB disease. In tumors, MDSC exhibit considerable plasticity and can undergo metabolic reprogramming from glycolysis to fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) to facilitate their immunosuppressive functions. In this review we look at the role of MDSC during M. tb infection and how their metabolic reprogramming aids in the exacerbation of active disease and highlight the possible MDSC-targeted metabolic pathways utilized during M. tb infection, suggesting ways to manipulate these cells in search of novel insights for anti-TB therapies.
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页数:19
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