Recent advances of fl-catenin small molecule inhibitors for cancer therapy: Current development and future perspectives

The Wnt/fl-catenin signaling pathway is involved in many cellular physiological processes, including embryonic development, cell proliferation and differentiation, tissue homeostasis and regeneration, etc. Aberrant activation of Wnt/fl-catenin signaling is one of the most typical features in the development and progression of cancer. Abnormal accumulation of fl-catenin, a core component of the Wnt/fl-catenin signaling pathway, is one of the main factors leading to abnormal activation of the Wnt/fl-catenin signaling pathway. Therefore, fl-catenin has become an important target for the development of anticancer drugs. Some fl-catenin small molecule inhibitors have been shown to have the potential to treat cancer, such as the specific fl-catenin/CBP antagonist PRI-724, which has entered phase I/II clinical trials. However, the development and application of fl-catenin inhibitors are still challenging due to their selectivity, specificity and physicochemical properties, etc. This review in-troduces the Wnt/fl-catenin signaling pathway, focuses on the research progress of fl-catenin small molecule inhibitors, and prospects for the development of drug in the future.