Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana

被引：34

作者：

Diaz, Jesus G. ^{[2
]}

Carmona, Armando J. ^{[2
]}

Torres, Fernando ^{[3
]}

Quintana, Jose ^{[3
]}

Estevez, Francisco ^{[3
]}

Herz, Werner ^{[1
]}

机构：

[1] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA

[2] Inst Univ Bioorgan Antonio Gonzalez, Tenerife, Spain

[3] Univ Palmas Gran Canaria, Ctr Ciencias Salud, Dept Bioquim Biol Mol & Fisiol, Gran Canaria, Spain

来源：

PLANTA MEDICA | 2008年 / 74卷 / 02期

关键词：

consolida oliveriana; Ranunculaceae; flavonoids; flavonoid acetates; cytoxicity; ALKALOIDS; APOPTOSIS; INDUCTION;

D O I：

10.1055/s-2008-1034278

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The flavonoids kaempferol, quercetin, trifolin, hyperoside 2 '' - and 6 ''- acetates, 7-glucotrifolin, biorobin and robinin were isolated from the aerial parts of Consolida oliveriana. Their derivatives kaempferol tetraacetate, quercetin pentaacetate, trifolin heptaacetate and hyperoside octaacetate exhibited significant cytotoxicity in vitro against three human cell lines HL-60, U937 and SK-MEL1 while hyperoside 2 ''-acetate, hyperoside-6 ''-acetate, glucotrifolin decaacetate and heptamethyltrifolin were inactive.

引用

页码：171 / 174

页数：4

共 15 条

[1] SIMULTANEOUS ANALYSIS OF FAMILIES OF SIGMOIDAL CURVES - APPLICATION TO BIOASSAY, RADIOLIGAND ASSAY, AND PHYSIOLOGICAL DOSE-RESPONSE CURVES [J].

DELEAN, A ;

MUNSON, PJ ;

RODBARD, D .

AMERICAN JOURNAL OF PHYSIOLOGY, 1978, 235 (02) :E97-E102

[2] Flavonol 3,7-glycosides and dihydroxyphenethyl glycosides from Aconitum napellus subsp lusitanicum [J].

Díaz, JG ;

Ruiz, JG ;

Días, BR ;

Sazatornil, JAG ;

Herz, W .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2005, 33 (02) :201-205

[3] The phenols and prodelphinidins of white clover flowers [J].

Foo, LY ;

Lu, Y ;

Molan, AL ;

Woodfield, DR ;

McNabb, WC .

PHYTOCHEMISTRY, 2000, 54 (05) :539-548

[4] Alkaloids from Consolida oliveriana [J].

Grandez, M ;

Madinaveitia, A ;

Gavín, JA ;

Alva, A ;

de la Fuente, G .

JOURNAL OF NATURAL PRODUCTS, 2002, 65 (04) :513-516

[5] The phenolic constituents and free radical scavenging activities of Gynura formosana Kiamnra [J].

Hou, WC ;

Lin, RD ;

Lee, TH ;

Huang, YH ;

Hsu, FL ;

Lee, MH .

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2005, 85 (04) :615-621

[6] Phenolic compounds from Hypericum perforatum [J].

Jürgenliemk, G ;

Nahrstedt, A .

PLANTA MEDICA, 2002, 68 (01) :88-91

[7]

Küçükislamoglu M, 2000, TURK J CHEM, V24, P191

[8] DPPH radical scavenging activity of two flavonol glycosides from Aconitum napellus sp lusitanicum [J].

Luis, J. C. ;

Valdes, F. ;

Martin, R. ;

Carmona, A. J. ;

Diaz, Jesus G. .

FITOTERAPIA, 2006, 77 (06) :469-471

[9]

MELNICHUK GG, 1971, UKRAINS KI BOTANICHN, V28, P525

[10]

Park Hye-Jeong, 2004, Journal of the Korean Society for Horticultural Science, V45, P138

← 1 2 →