Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

被引：44

作者：

Chen, Shuang ^{[1
]}

Xu, Da ^{[1
]}

Fan, Liu ^{[1
]}

Fang, Zhi ^{[1
]}

Wang, Xiufeng ^{[1
]}

Li, Man ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Neurol, Union Hosp, Tongji Med Coll, Wuhan, Peoples R China

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2022年 / 14卷

基金：

中国国家自然科学基金;

关键词：

N-methyl-D-aspartate receptor; epilepsy; anti-NMDAR encephalitis; D-serine; glutamate; excitotoxicity; CREB; epigenomics; EXCITOTOXIC NEURONAL DEATH; CELL-DEATH; SYNAPTIC PLASTICITY; STATUS EPILEPTICUS; D-SERINE; HIPPOCAMPAL NEURODEGENERATION; INDUCED NEUROTOXICITY; COGNITIVE FUNCTION; GRIN2B MUTATION; CROSS-TALK;

D O I：

10.3389/fnmol.2021.797253

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal discharges, nerve conduction, neuron injury and inflammation, thereby they may participate in epileptogenesis. NMDARs belong to a family of ionotropic glutamate receptors that play essential roles in excitatory neurotransmission and synaptic plasticity in the mammalian CNS. Despite numerous studies focusing on the role of NMDAR in epilepsy, the relationship appeared to be elusive. In this article, we reviewed the regulation of NMDAR and possible mechanisms of NMDAR in epilepsy and in respect of onset, development, and treatment, trying to provide more evidence for future studies.

引用

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