How far are we from the clinical use of placental-derived mesenchymal stem cells?

被引：21
作者：
Fierabracci, Alessandra [1 ,4 ]
Lazzari, Lorenza [2 ,4 ]
Muraca, Maurizio [4 ]
Parolini, Ornella [3 ,4 ]
机构：
[1] IRCCS, Immunol & Pharmacotherapy Area, Autoimmun Lab, Bambino Gesu Childrens Hosp, I-00146 Rome, Italy
[2] Cell Factory Fdn IRCCS Ca Granda Osped Maggiore P, I-20129 Milan, Italy
[3] Fdn Poliambulanza, Ist Osped, Ctr Ric, I-25124 Brescia, Italy
[4] Bambino Gesu Pediat Hosp, Autoimmun Lab, Immunol & Pharmacotherapy Area, Rome, Italy
来源：
EXPERT OPINION ON BIOLOGICAL THERAPY | 2015年 / 15卷 / 05期
关键词：
isolation procedure; phenotype; placenta; placental mesenchymal stem cells; safety; stability; therapeutic application; tumorigenesis; INDUCED LUNG FIBROSIS; AMNIOTIC MEMBRANE; ALZHEIMERS-DISEASE; CONDITIONED MEDIUM; FETAL MEMBRANES; TERM PLACENTA; MOUSE MODEL; TRANSPLANTATION; DIFFERENTIATION; CULTURES;
D O I：
10.1517/14712598.2015.1000856
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In recent years, multiple studies have investigated the biology and clinical applications of mesenchymal stem cells (MSCs), trying to define their markers, and elucidate their effects in animal models. MSCs are available from different tissues, and the use of placental-derived MSCs (PMSCs) for treating a variety of disorders is on the forefront. Herein, we discuss the most recent findings regarding the standardization of their isolation procedure and phenotype, along with advantages and limitations of their use. We also discuss the safety of the placental cell products, including the issue of senescence and mutagenesis of PMSCs, and efficacy from preclinical studies.
引用
收藏
页码：613 / 617
页数：5
相关论文
共 33 条
[1]   Conditioned medium from amniotic membrane-derived cells prevents lung fibrosis and preserves blood gas exchanges in bleomycin-injured mice-specificity of the effects and insights into possible mechanisms [J].
Cargnoni, Anna ;
Piccinelli, Ester Cotti ;
Ressel, Lorenzo ;
Rossi, Daniele ;
Magatti, Marta ;
Toschi, Ivan ;
Cesari, Valentina ;
Albertini, Mariangela ;
Mazzola, Silvia ;
Parolini, Ornella .
CYTOTHERAPY, 2014, 16 (01) :17-32
[2]   Conditioned medium from amniotic mesenchymal tissue cells reduces progression of bleomycin-induced lung fibrosis [J].
Cargnoni, Anna ;
Ressel, Lorenzo ;
Rossi, Daniele ;
Poli, Alessandro ;
Arienti, Davide ;
Lombardi, Guerino ;
Parolini, Ornella .
CYTOTHERAPY, 2012, 14 (02) :153-161
[3]   Transplantation of Allogeneic and Xenogeneic Placenta-Derived Cells Reduces Bleomycin-Induced Lung Fibrosis [J].
Cargnoni, Anna ;
Gibelli, Lucia ;
Tosini, Alessandra ;
Signoroni, Patrizia Bonassi ;
Nassuato, Claudia ;
Arienti, Davide ;
Lombardi, Guerino ;
Albertini, Alberto ;
Wengler, Georg S. ;
Parolini, Ornella .
CELL TRANSPLANTATION, 2009, 18 (04) :405-422
[4]   A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis [J].
Chambers, Daniel C. ;
Enever, Debra ;
Ilic, Nina ;
Sparks, Lisa ;
Whitelaw, Kylie ;
Ayres, John ;
Yerkovich, Stephanie T. ;
Khalil, Dalia ;
Atkinson, Kerry M. ;
Hopkins, Peter M. A. .
RESPIROLOGY, 2014, 19 (07) :1013-1018
[5]  
Corrao S, 2013, HISTOL HISTOPATHOL, V28, P1235, DOI 10.14670/HH-28.1235
[6]   Recent Advances in Mesenchymal Stem Cell Immunomodulation: The Role of Microvesicles [J].
Fierabracci, Alessandra ;
Del Fattore, Andrea ;
Luciano, Rosa ;
Muraca, Marta ;
Teti, Anna ;
Muraca, Maurizio .
CELL TRANSPLANTATION, 2015, 24 (02) :133-149
[7]   Transplantation of Placenta-Derived Mesenchymal Stem Cells in the EAE Mouse Model of MS [J].
Fisher-Shoval, Yonit ;
Barhum, Yael ;
Sadan, Ofer ;
Yust-Katz, Shlomit ;
Ben-Zur, Tali ;
Lev, Nirit ;
Benkler, Chen ;
Hod, Moshe ;
Melamed, Eldad ;
Offen, Daniel .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2012, 48 (01) :176-184
[8]   DEVELOPMENT OF FIBROBLAST COLONIES IN MONOLAYER CULTURES OF GUINEA-PIG BONE MARROW AND SPLEEN CELLS [J].
FRIEDENSTEIN, AJ ;
CHAILAKHJAN, RK ;
LALYKINA, KS .
CELL AND TISSUE KINETICS, 1970, 3 (04) :393-+
[9]   Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells [J].
Groh, ME ;
Maitra, B ;
Szekely, E ;
Koç, ON .
EXPERIMENTAL HEMATOLOGY, 2005, 33 (08) :928-934
[10]   High Incidence of Contaminating Maternal Cell Overgrowth in Human Placental Mesenchymal Stem/Stromal Cell Cultures: A Systematic Review [J].
Heazlewood, Celena F. ;
Sherrell, Helen ;
Ryan, Jennifer ;
Atkinson, Kerry ;
Wells, Christine A. ;
Fisk, Nicholas M. .
STEM CELLS TRANSLATIONAL MEDICINE, 2014, 3 (11) :1305-1311
1234