177Lu-FAPI Therapy in a Patient With End-Stage Metastatic Pancreatic Adenocarcinoma

被引：30
作者：
Kaghazchi, Fatemeh [1 ]
Aghdam, Ramin Akbarian [2 ]
Haghighi, Shirin [3 ]
Vali, Reza [4 ]
Adinehpour, Zohreh [1 ]
机构：
[1] Khatam Hosp, Dept PET CT, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci Tehran, Nucl Med & Mol Imaging, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci Tehran, Taleghani Hosp, Oncol, Tehran, Iran
[4] Univ Toronto, Toronto, ON, Canada
来源：
CLINICAL NUCLEAR MEDICINE | 2022年 / 47卷 / 03期
关键词：
Ga-68-FAPI-46; F-18-FDG; PET/CT; pancreatic cancer; Lu-177-FAPI-46; FIBROBLAST ACTIVATION PROTEIN; CANCER;
D O I：
10.1097/RLU.0000000000004021
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
A 52-year-old woman with metastatic pancreatic adenocarcinoma underwent imaging with F-18-FDG PET/CT and Ga-68-FAPI-46 PET/CT, which demonstrated malignancy recurrence in the surgical bed with multiple metastatic lesions, more extensive on Ga-68-FAPI-46 PET/CT. The patient was a candidate for therapy with Lu-177-FAPI-46 due to high uptake of lesions in Ga-68-FAPI-46 images and no other available therapeutic option. Posttreatment Lu-177-FAPI-46 scans showed rather rapid washout of the radiopharmaceutical from tumoral lesions. This case report suggests that, although Ga-68-FAPI-46 is a promising agent for tumor imaging, Lu-177-FAPI-46 may not be an optimal compound for theranostic applications.
引用
收藏
页码：E243 / E245
页数：3
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