Target cell-induced apoptosis in IL-2-activated human natural killer cells

被引:7
|
作者
Taga, K
Yamauchi, A
Bloom, ET
机构
[1] US FDA, Div Hematol Prod, Ctr Biol Evaluat Res, Bethesda, MD 20014 USA
[2] US FDA, Div Cellular & Gene Therapies, Ctr Biol Evaluat Res, Bethesda, MD 20014 USA
关键词
IL-2; activated; NK cells; natural Killer cells; target cell induced apoptosis; apoptosis;
D O I
10.3109/10428199909058402
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We demonstrated that tumor cells induce cell death in lymphokine-activated NK (LAK) cells, but not in non-activated NK cells. Cell death in LAK cells involves nuclear condensation and DNA cleavage, all of which are characteristic features of apoptosis. The mechanism involves signaling through integrins and requires src family tyrosine kinases and protease activities. Engagement of an apoptotic signal molecule, Fas, may also trigger LAK cell death by apoptosis. It appears that LAK cells rapidly die by apoptosis after attacking tumor cells. This phenomenon may provide a means for potential tumor target cells to escape from natural immunosurveillance during therapeutic interventions such as those using IL-2 or LAK cells.
引用
收藏
页码:451 / 458
页数:8
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