Novel immune scoring dynamic nomograms based on B7-H3, B7-H4, and HHLA2: Potential prediction in survival and immunotherapeutic efficacy for gallbladder cancer

被引：6

作者：

Lv, Chao ^{[1
]}

Han, Shukun ^{[1
]}

Wu, Baokang ^{[1
]}

Liang, Zhiyun ^{[1
]}

Li, Yang ^{[1
]}

Zhang, Yizhou ^{[1
]}

Lang, Qi ^{[1
]}

Zhong, Chongli ^{[1
]}

Fu, Lei ^{[1
]}

Yu, Yang ^{[2
]}

Xu, Feng ^{[1
]}

Tian, Yu ^{[1
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Gen Surg, Shenyang, Liaoning, Peoples R China

[2] Jinzhou Med Univ, Dept Surg, Jinzhou, Liaoning, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

B7-H3 (CD276); B7-H4 (B7x; B7-H5); tumor infiltrating lymphocytes (TILs); gallbladder cancer; PROGNOSTIC-FACTORS; CLINICAL IMPACT; TARGETING B7-H3; SOLID TUMORS; EXPRESSION; CARCINOMA; RECEPTOR; PD-L1; GEMCITABINE; VALIDATION;

D O I：

10.3389/fimmu.2022.984172

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BackgroundGallbladder cancer (GBC) is a mortal malignancy with limited therapeutic strategies. We aimed to develop novel immune scoring systems focusing on B7-H3, B7-H4, and HHLA2. We further investigated their potential clinical effects in predicting survival and immunotherapeutic efficacy for GBC. MethodsThis was a retrospective cohort study in a single center that explored the expression characteristics of B7-H3, B7-H4, and HHLA2. The immune scoring nomograms for prognostic were developed via logistic regression analyses. Their performance was evaluated using the Harrell concordance index (C-index) and decision curves analysis (DCA), and validated with calibration curves. ResultsB7-H3, B7-H4, and HHLA2 manifested with a relatively high rate of co-expression patterns in GBC tissues. They were associated with worse clinicopathological stage, suppression of immune microenvironment, and unfavorable prognosis in postoperative survival. B7 stratification established based on B7-H3, B7-H4, and HHLA2 was an independent prognostic predictor (p<0.05 in both groups). Moreover, immune stratification was also successfully constructed based on B7 stratification and the density of CD8(+) TILs (all p<0.001). The prediction models were developed based on B7-/or immune stratification combined with the TNM/or Nevin staging system. These novel models have excellent discrimination ability in predicting survival and immunotherapeutic efficacy for GBC patients by DCA and clinical impact plots. Finally, dynamic nomograms were developed for the most promising clinical prediction models (B7-TNM model and Immune-TNM model) to facilitate prediction. ConclusionsImmune scoring systems focusing on B7-H3, B7-H4, and HHLA2 may effectively stratify the prognosis of GBC. Prognostic nomograms based on novel immune scoring systems may potentially predict survival and immunotherapeutic efficacy in GBC. Further valid verification is necessary.

引用

页数：16

共 58 条

[1] Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3 [J].