Fucoidin prevents Clostridium difficile toxin-A-induced ileal enteritis in mice

被引：11

作者：

Barreto, A. R. F. ^{[1
]}

Cavalcante, I. C. ^{[2
]}

Castro, M. V. ^{[2
]}

Junqueira, A. F. T. A. ^{[1
]}

Vale, M. R. ^{[2
]}

Ribeiro, R. A. ^{[2
]}

Souza, M. H. L. P. ^{[2
]}

Brito, G. A. C. ^{[1
,2
]}

机构：

[1] Univ Fed Ceara, Dept Morphol, Fac Med, BR-60416030 Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Dept Physiol & Pharmacol, BR-60416030 Fortaleza, Ceara, Brazil

来源：

DIGESTIVE DISEASES AND SCIENCES | 2008年 / 53卷 / 04期

关键词：

fucoidin; Clostridium difficile toxin A; inflammation; ADA activity;

D O I：

10.1007/s10620-007-9957-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Recent reports suggest increased incidence and severity of Clostridium difficile-associated diseases. These facts have raised the need for additional clarification of pathogenesis and for a search for new therapeutic strategies. This study evaluated the effects of the polysaccharide fucoidin, an L-selectin blocker, on toxin-A-induced mouse enteritis. Fucoidin (25 mg/kg) or saline (0.1 ml) were injected systemically (ocular plexus) 5 min prior to local challenge with toxin A (5 mu g/ileal loop) or phosphate-buffered saline (PBS). Intestinal fluid volume/length and ileal loop weight/length ratios were calculated 3 h later. Ileal tissues were collected for histopathology and measurement of myeloperoxidase and adenosine deaminase activity. Fucoidin significantly (P < 0.05) prevented the toxin-A-induced increase in weight/length and volume/length ratios and reduced mucosal disruption, as shown in histopathology. Fucoidin also significantly (P < 0.05) reduced toxin-A-induced myeloperoxidase and adenosine deaminase activities. In conclusion, fucoidin reduces tissue injury and inflammation in toxin-A-induced mouse enteritis.

引用

页码：990 / 996

页数：7

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