Expanding the Boundaries of Embryonic Stem Cells

被引：45

作者：

Ben-David, Uri ^{[1
]}

Kopper, Oded ^{[1
]}

Benvenisty, Nissim ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Dept Genet, Stem Cell Unit, Silberman Inst Life Sci, IL-91904 Jerusalem, Israel

来源：

CELL STEM CELL | 2012年 / 10卷 / 06期

基金：

以色列科学基金会;

关键词：

TRANSCRIPTIONAL REGULATORY CIRCUITRY; DEFINED CULTURE-SYSTEMS; HOMOLOGOUS RECOMBINATION; HUMAN ESCS; CHROMOSOMAL-ABERRATIONS; LINEAGE SPECIFICATION; INTERACTION NETWORK; DRUG DISCOVERY; NONCODING RNAS; OPEN CHROMATIN;

D O I：

10.1016/j.stem.2012.05.003

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The boundaries of embryonic stem cell (ESC) research have extended considerably in recent years in several important ways. Alongside a deeper understanding of the pluripotent state, ESCs have been successfully integrated into various fields, such as genomics, epigenetics, and disease modeling. Significant progress in cell fate control has pushed directed differentiation and tissue engineering further than ever before and promoted clinical trials. The geographical distribution of research activity has also expanded, especially for human ESCs. This review outlines these developments and future challenges that remain.

引用

页码：666 / 677

页数：12

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