Copper-Catalyzed Stereoselective Domino Synthesis of (Z)-3-Methyleneisoindolin-1-one

被引：15

作者：

Hazarika, Debojit ^{[1
]}

Phukan, Prodeep ^{[1
]}

机构：

[1] Gauhati Univ, Dept Chem, Gauhati 781014, Assam, India

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 09期

关键词：

Alkyne; Cu(DMAP)(4)I]I; 2-Halobenzamide; 3-Methyleneisoindolin-1-one; Propiolic acid; 1ST TOTAL-SYNTHESIS; ONE-POT SYNTHESIS; C-H ACTIVATION; TERMINAL ALKYNES; SUBSTITUTED; 3-METHYLENEISOINDOLIN-1-ONES; HIGHLY REGIO; (Z)-3-ARYL(ALKYL)IDENE ISOINDOLIN-1-ONES; ELECTROPHILIC CYCLIZATION; INHIBITORY-ACTIVITY; DERIVATIVES;

D O I：

10.1002/slct.201702875

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Stereoselective synthesis of (Z)-3-methyleneisoindolin-1-one has been achieved via intermolecular coupling of terminal alkynes and 2-halobenzamide using a square pyramidal [Cu(DMAP)(4)I]I complex as catalyst within a short time. This cross coupling reaction features the use of unprotected 2-halobenzamide to achieve excellent yield of corresponding isoindolin-1-ones with free NH group. The catalyst was also found to be equally active for N-substituted 2-halobenzamide, phenyl propiolic acids and silylated alkyne.

引用

页码：2474 / 2478

页数：5

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