Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials

被引：60

作者：

Naithani, Rajesh ^{[1
]}

Huma, Loredana C. ^{[1
]}

Moriarty, Robert M. ^{[1
,2
]}

McCormick, David L. ^{[1
]}

Mehta, Rajendra G. ^{[1
]}

机构：

[1] IIT, Res Inst, Drug Discovery Div, Chicago, IL 60616 USA

[2] Univ Illinois, Dept Chem, Chicago, IL 60680 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2008年 / 15卷 / 11期

关键词：

cancer chemoprevention; flavonoids; phytochemicals; phase trials; mechanisms; epidemiology;

D O I：

10.2174/092986708784221403

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer chemoprevention refers to the use of pharmacological agents to inhibit, delay or reverse the multi-step process of carcinogenesis. The last two decades in particular have witnessed explosive growth in this emerging field of cancer chemoprevention. Extensive efforts to evaluate possible application of various chemopreventive agents, in individuals at high risk of neoplastic development have been carried out. Epidemiological studies suggest a protective role of several agents in reducing the risk of cancer. The protective action of all these agents is explained as a combination of various proposed mechanisms involving anti-oxidant, anti-inflammatory, immunomodulatory action, apoptosis induction, molecular association with carcinogen, cell cycle arrest, cell differentiation induction, antimicrobial effect, and anti-angiogenesis etc. Large numbers of candidate substances such as phytochemicals and their synthetic derivatives have been identified by a combination of in vitro and in vivo studies in a wide range of biological assays. However, a comprehensive description of these chemopreventive agents has not been extensively reviewed. In this review we discuss cancer chemopreventive agents in relation to their source, efficacy in cancer chemopreventive action in vivo and epidemiological data. The experimental carcinogenesis studies in different biological models, in addition to the contribution from our laboratory are summarized.

引用

页码：1044 / 1071

页数：28

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