Synthesis of bioactive natural products and their analogs at room temperature - an update

Sustainability is a concept that is employed to distinguish methods and procedures that can ensure the long-term productivity of the environment as it includes environmental, social, and economic dimensions. New generations can live on this planet with less hazardous substances and minimum requirement of energy for chemical transformations as green chemistry is related to creativity and the development of innovative research. Among the 12 principles of this clean chemistry, the sixth principle is devoted to the "design of energy efficiency" which discloses that less or the minimum amount of energy is required to conduct a specific reaction with optimum productivity. The most successful way to save energy is to construct strategies/methodologies that are capable enough to carry out the chemical transformations at ambient temperature and standard pressure. Hence, the present review wishes to cover the synthesis of bioactive natural products and their derivatives at room temperature. Bioactive secondary metabolites play a crucial role in the drug discovery together with drug development process; chiefly anticancer along with antibiotic molecules is noticeably enriched with molecules of natural origin. Natural sources, structures, and biological activities of natural products are highlighted in this review and it is also aimed to offer an overview of the design and synthesis of bioactive natural products and their analogs at room temperature for the first time efficiently.