Interaction between 16α,17α-cyclopropane progesterone and progesterone receptors in rat uterus

被引：0
|
作者：
Smirnov, AN
Pokrovskaya, EV
Shevchenko, VP
Levina, IS
Kamernitskii, AV
机构：
[1] Moscow MV Lomonosov State Univ, Fac Biol, Lab Endocrinol, Moscow, Russia
[2] Russian Acad Sci, Inst Mol Genet, Lab Radiolabeled Bioact Subst, Moscow 123182, Russia
[3] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Grp Steroid & Hydroxylipine Chem, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1998年 / 125卷 / 05期
基金：
俄罗斯基础研究基金会;
关键词：
progesterone; progesterone receptor; progesterone analog; steroid-receptor interaction;
D O I：
10.1007/BF02445287
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Binding of H-3-16 alpha, 17 alpha-cyclopropanoprogesterone (CPG) and SH-progesterone (PG) to progesterone receptors in soluble fraction of rat uterus is studied. It is shown that CPG and PG specifically bind to the protein with similar affinity and binding capacity. Unlabeled PG competitively inhibits the binding of CPG, and unlabeled CPG competitively inhibits the binding of PF with the same efficiency. Dissociation of CPG- and PG-receptor complexes is characterized by the same dissociation constant.
引用
收藏
页码：471 / 473
页数：3
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