The Metabolome of Carbapenem-Resistant Klebsiella pneumoniae Infection in Plasma

被引：4

作者：

Wen, Zhongwei ^{[1
]}

Liu, Mei ^{[1
]}

Rui, Dong ^{[1
]}

Liao, Xiaoxiao ^{[1
]}

Su, Rui ^{[1
]}

Tang, Zhenming ^{[1
]}

Wen, Zhineng ^{[1
]}

Ling, Zhougui ^{[1
]}

机构：

[1] Guangxi Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 4, 156 Heping Rd, Liuzhou 545005, Guangxi Provinc, Peoples R China

来源：

DISEASE MARKERS | 2021年 / 2021卷

关键词：

D O I：

10.1155/2021/7155772

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim. Carbapenem-resistant Klebsiella pneumoniae- (CR-Kp-) mediated infections represent a challenge for clinical practitioners due to their expanding prevalence in hospital environments and antibiotic resistance. However, few studies have shown metabolic changes of carbapenem-resistant Klebsiella pneumoniae and CR-Kp-negative patients, and relevant studies are urgently needed. Methods. In this study, we comprehensively profile the metabolites of 20 CR-Kp-positive and 18 CR-Kpnegative patients in plasma by using 2D gas chromatography-time-of-flight mass spectrometry (GCxGC-TOFMS). Results. We identified 58 metabolites that were carbapenem-resistant Klebsiella pneumoniae-associated. N-Acetyl glucosamine, butanedioic acid, and myoinositol play a significant character in CR-Kp infection. Conclusions. Our study provides valuable data to serve as potential targets for developing therapies against CR-Kp infection.

引用

页数：9

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