Thermodynamic equilibrium of hydrocortisone form I in different solvent systems

被引：15

作者：

He, Meng ^{[1
]}

Wang, Yongli ^{[1
,2
]}

Xiao, Liping ^{[1
]}

Lou, Yajing ^{[1
]}

Su, Nannan ^{[1
]}

Li, Yang ^{[1
]}

Hao, Hongxun ^{[1
,2
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China

[2] Coinnovat Ctr Chem & Chem Engn Tianjin, Tianjin 300072, Peoples R China

来源：

FLUID PHASE EQUILIBRIA | 2017年 / 454卷

基金：

美国国家科学基金会;

关键词：

Hydrocortisone form I; Solubility; Pure solvents; Binary solvent system; Thermodynamic properties; PLUS WATER MIXTURES; PURE SOLVENTS; SOLUBILITY;

D O I：

10.1016/j.fluid.2017.09.007

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The solubility of hydrocortisone form I in seven pure solvents and one kind of binary solvent system from (278.15-323.15) K was experimentally determined by using a dynamic method under atmospheric pressure. The results show that the solubility of hydrocortisone form I monotonously increases with increasing of temperature and reaches the maximum at ethanol molar fraction of 0.60 in binary solvent mixture of ethyl acetate and ethanol at constant temperature. The experimental solubility data in pure solvents were correlated by the modified Apelblat equation, the lambda h equation and the van't Hoff equation while the experimental solubility data in binary solvent systems were correlated by the modified Apelblat equation and the CNIBS/R-K model. In addition, the apparent thermodynamic properties (enthalpy, entropy, and Gibbs energy) of mixing processes and dissolution processes were also calculated based on the NRTL model. The calculated results indicate that the dissolution process of hydrocortisone form I in tested solvents is spontaneous and endothermic. (C) 2017 Published by Elsevier B.V.

引用

页码：1 / 10

页数：10

共 28 条

[1] SOLVENT ACTIVITY ALONG A SATURATION LINE AND SOLUBILITY OF HYDROGEN-BONDING SOLIDS [J].

BUCHOWSKI, H ;

KSIAZCZAK, A ;

PIETRZYK, S .

JOURNAL OF PHYSICAL CHEMISTRY, 1980, 84 (09) :975-979

[2] Determination and correlation of the solubility for diosgenin in alcohol solvents [J].

Chen, Fei-xiong ;

Zhao, Ming-rui ;

Liu, Chuo-chuo ;

Peng, Fei-fei ;

Ren, Bao-zeng .

JOURNAL OF CHEMICAL THERMODYNAMICS, 2012, 50 :1-6

[3] Effect of solvent on the crystal structure and habit of hydrocortisone [J].

Chen, Jianxin ;

Wang, Jingkang ;

Ulrich, Joachim ;

Yin, Qiuxiang ;

Xue, Lvzhong .

CRYSTAL GROWTH & DESIGN, 2008, 8 (05) :1490-1494

[4] Crystal growth, structure and morphology of hydrocortisone methanol solvate [J].

Chen, JX ;

Wang, JK ;

Zhang, Y ;

Wu, H ;

Chen, W ;

Guo, ZC .

JOURNAL OF CRYSTAL GROWTH, 2004, 265 (1-2) :266-273

[5] Solubility of 11β-hydroxypregna-1,4,16-triene-3,20-dione in different solvents [J].

Chen, Qiaoli ;

Wang, Yongli ;

Wu, Xiaohong ;

Wang, Jingkang .

JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2008, 53 (06) :1414-1416

[6] Solution Thermodynamics and Preferential Solvation of Sulfamerazine in Methanol plus Water Mixtures [J].

Delgado, Daniel R. ;

Martinez, Fleming .

JOURNAL OF SOLUTION CHEMISTRY, 2015, 44 (02) :360-377

[7] Predicting lattice energy of organic crystals by density functional theory with empirically corrected dispersion energy [J].

Feng, SX ;

Li, TL .

JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2006, 2 (01) :149-156

[8] Thermodynamic analysis of the solubility of ketoprofen in some propylene glycol plus water cosolvent mixtures [J].

Gantiva, Mauricio ;

Martinez, Fleming .

FLUID PHASE EQUILIBRIA, 2010, 293 (02) :242-250

[9] Solubility of dexamethasone sodium phosphate in different solvents [J].

Hao, HX ;

Wang, JK ;

Wang, YL .

JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2004, 49 (06) :1697-1698

[10] Measurement and prediction of solubility of paracetamol in water-isopropanol solution. Part 1. Measurement and data analysis [J].

Hojjati, H. ;

Rohani, S. .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2006, 10 (06) :1101-1109

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