Characterization of murine leukemia virus restriction in mammals

被引：53

作者：

Besnier, C

Ylinen, L

Strange, B

Lister, A

Takeuchi, Y

Goff, SP

Towers, GJ

机构：

[1] UCL, Wohl Virion Ctr, Dept Immunol & Mol Pathol, London W1T 4JF, England

[2] UCL, Dept Biol, London WC1E 6BT, England

[3] Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USA

[4] Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 24期

关键词：

D O I：

10.1128/JVI.77.24.13403-13406.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Restriction of murine leukemia virus (MLV) was examined in cells from a range of mammals. All nonmurine restrictions were saturable blocks to N-tropic MLV infection, and several were prior to reverse transcription. We demonstrate restriction in cells from bat and show that if we express the murine restriction factor Fv1 in human cells, then Fv1, not the human host, defines the stage at which infection is blocked.

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页码：13403 / 13406

页数：4

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