Synthesis of Pentablock and Multibranched Copolymers Bearing Poly(ethylene glycol), Hyperbranched Polyglycidol, and Poly(L-lactide) with Biocompatibility for Controlled Drug Release

被引:12
作者
Wang, Jing [1 ]
Kim, Min Hee [1 ]
Kang, Dong Eun [1 ]
Suh, Hongsuk [2 ,3 ]
Kim, Il [1 ]
机构
[1] Pusan Natl Univ, Dept Polymer Sci & Engn, World Class Univ Ctr Synthet Polymer Bioconjugate, Pusan 609735, South Korea
[2] Pusan Natl Univ, Dept Chem, Pusan 609735, South Korea
[3] Pusan Natl Univ, Chem Inst Funct Mat, Pusan 609735, South Korea
关键词
biocompatibility; block copolymers; branched polyglycidol; drug delivery systems; micelles; ring-opening polymerization; FORCE-FIELD; ANTITUMOR-ACTIVITY; MICELLES;
D O I
10.1002/pola.26040
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
A series of multibranched pentablock copolymer (mBr5BlC), poly(L-lactide)-b-HBP-b-poly(ethylene glycol)-b-HBP-b-poly(L-lactide) (HBP = hyperbranched polyglycidol), has been synthesized by ring-opening multibranching polymerization of glycidol using bifunctional poly(ethylene glycol) [PEG; molecular weight (MW) = 1000] as an initiator, followed by ring-opening polymerization (ROP) of L-lactide in the presence of stannous octoate. The ROP of different amounts of L-lactide on HBP-b-PEG-b-HBP [MW = 2550; polydispersity index (PDI) = 1.08] yielded a series of the targeted mBr5BlCs of the MW range of 4360-15,300 with narrow PDI. All the mBr5BlCs have been well demonstrated to be in possession of good biocompatibility as biomaterials for various applications in biological medicine areas. The mBr5BlCs with tunable MW exhibited promising controllability in self-assembly into spherical micellar structures with an average diameter range of 59-140 nm, which have no acute and intrinsic cytotoxicity against normal cells and provide a convenient strategy for drug loading. The anticancer drug doxorubicin was demonstrated to have a good affinity with the copolymer system, and its controlled release was performed in various pHs. (C) 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 50: 2553-2564, 2012
引用
收藏
页码:2553 / 2564
页数:12
相关论文
共 34 条
[1]  
Accelrys Inc, 2003, DISC AM CELL MOD VER
[2]   Preparation of Multifunctional Polymeric Micelles for Antiviral Treatment [J].
Ahn, Yong Sik ;
Baik, Hye Jung ;
Lee, Bo Reum ;
Lee, Eun Seong ;
Oh, Kyung Taek ;
Lee, Don Haeng ;
Youn, Yu Seok .
MACROMOLECULAR RESEARCH, 2010, 18 (08) :747-752
[3]  
Allen M. P., 2017, COMPUTER SIMULATION
[4]   LIPOSOMES CONTAINING SYNTHETIC LIPID DERIVATIVES OF POLY(ETHYLENE GLYCOL) SHOW PROLONGED CIRCULATION HALF-LIVES INVIVO [J].
ALLEN, TM ;
HANSEN, C ;
MARTIN, F ;
REDEMANN, C ;
YAUYOUNG, A .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1066 (01) :29-36
[5]   In vivo antitumor activity of the folate-conjugated pH-Sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments [J].
Bae, Younsoo ;
Nishiyama, Nobuhiro ;
Kataoka, Kazunori .
BIOCONJUGATE CHEMISTRY, 2007, 18 (04) :1131-1139
[6]   Studies on aliphatic polyesters.: Part II.: Ab initio, density functional and force field studies of model molecules with two carboxyl groups [J].
Blomqvist, J ;
Mannfors, B ;
Pietilä, LO .
JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 2000, 531 :359-374
[7]   Studies on aliphatic polyesters I:: Ab initio, density functional and force field studies of esters with one carboxyl group [J].
Blomqvist, J ;
Ahjopalo, L ;
Mannfors, B ;
Pietilä, LO .
JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 1999, 488 :247-262
[8]   Thermo-responsive polymer nanoparticles with a core-shell micelle structure as site-specific drug carriers [J].
Cammas, S ;
Suzuki, K ;
Sone, C ;
Sakurai, Y ;
Kataoka, K ;
Okano, T .
JOURNAL OF CONTROLLED RELEASE, 1997, 48 (2-3) :157-164
[9]   Doxorubicin: The Good, the Bad and the Ugly Effect [J].
Carvalho, Cristina ;
Santos, Renato X. ;
Cardoso, Susana ;
Correia, Sonia ;
Oliveira, Paulo J. ;
Santos, Maria S. ;
Moreira, Paula I. .
CURRENT MEDICINAL CHEMISTRY, 2009, 16 (25) :3267-3285
[10]   Stabilized polymeric micelles by electrostatic interactions for drug delivery system [J].
Cha, Eui-Joon ;
Kim, Ju Eun ;
Ahn, Cheol-Hee .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 38 (04) :341-346