Neurostructural abnormalities in pediatric anxiety disorders

被引：60

作者：

Strawn, Jeffrey R. ^{[1
,2
]}

Hamm, Lisa ^{[3
]}

Fitzgerald, Daniel A. ^{[3
]}

Fitzgerald, Kate D. ^{[4
]}

Monk, Christopher S. ^{[4
]}

Phan, K. Luan ^{[3
,5
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH 45267 USA

[2] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Child & Adolescent Psychiat, Cincinnati, OH 45229 USA

[3] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA

[4] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA

[5] Jesse Brown VA Med Ctr, Mental Hlth Serv Line, Chicago, IL USA

来源：

JOURNAL OF ANXIETY DISORDERS | 2015年 / 32卷

关键词：

Children; Adolescent; Voxel-based morphometry (VBM); Anxiety; Amygdala; Ventrolateral prefrontal cortex (VLPFC); Cingulate cortex; VENTROLATERAL PREFRONTAL CORTEX; COGNITIVE-BEHAVIORAL THERAPY; ANTERIOR CINGULATE CORTEX; VOXEL-BASED MORPHOMETRY; ANGRY FACES; ADOLESCENTS; CHILDREN; AMYGDALA; FEAR; RELIABILITY;

D O I：

10.1016/j.janxdis.2015.03.004

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Functional neuroimaging studies have consistently demonstrated abnormalities in fear and threat processing systems in youth with anxiety disorders; however, the structural neuroanatomy of these systems in children and adolescents remains largely unknown. Using voxel-based morphometry (VBM), gray matter volumes were compared between 38 medication-free patients with anxiety disorders (generalized anxiety disorder; social phobia; separation anxiety disorder, mean age: 14.4 +/- 3 years) and 27 comparison subjects (mean age: 14.8 +/- 4 years). Compared to healthy subjects, youth with anxiety disorders had larger gray matter volumes in the dorsal anterior cingulate and had decreased gray matter volumes in the inferior frontal gyrus (ventrolateral prefrontal cortex), postcentral gyrus, and cuneus/precuneus. These data suggest the presence of structural differences in regions previously implicated in the processing and regulation of fear in pediatric patients with anxiety disorders. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：81 / 88

页数：8

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