Validity of a two-item screen for early psychosis

被引:12
作者
Phalen, Peter L. [1 ,2 ]
Rouhakhtar, Pamela Rakhshan [3 ]
Millman, Zachary B. [3 ]
Thompson, Elizabeth [4 ]
DeVylder, Jordan [5 ]
Mittal, Vijay [6 ]
Carter, Evan [7 ]
Reeves, Gloria [1 ]
Schiffman, Jason [3 ]
机构
[1] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA
[2] Baltimore VA Med Ctr, MIRECC, Baltimore, MD USA
[3] Univ Maryland, Dept Psychol, 1000 Hilltop Circle, Baltimore, MD 21250 USA
[4] Brown Univ, Dept Psychiat & Human Behav, Alpert Med Sch, Providence, RI 02912 USA
[5] Fordham Univ, Grad Sch Social Serv, New York, NY 10023 USA
[6] Northwestern Univ, Dept Psychol, Evanston, IL USA
[7] US Army Res Lab, HRED, Adelphi, MD USA
关键词
PRODROMAL QUESTIONNAIRE; HIGH-RISK; ADOLESCENTS; VALIDATION; PQ;
D O I
10.1016/j.psychres.2018.11.002
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Well-validated screening tools have been developed to identify people at high risk for psychosis, but these are rarely used outside of specialty clinics or research settings. The development of extremely brief and simple screening tools could increase dissemination, especially in settings with low buy-in such as those with low base rates of psychosis and/or time constraints. We sought to identify such a brief measure by modeling participant responses to three psychosis screening questionnaires (Prime Screen; Prodromal Questionnaire-Brief; Youth Psychosis At Risk Questionnaire) in a sample of 139 help-seeking individuals and 335 college students (age range: 12-25). Two screening questions with especially strong information characteristics were identified: "Do you see things that others can't or don't see?" and "Have you ever felt that someone was playing with your mind?" (Alternative two-item screens with similarly strong properties were also identified and validated using uncertainty quantified through Bayesian modeling.) The resulting measure was validated against clinician ratings of psychosis. The screen performed with a sensitivity of 53% and specificity 98% for clinically significant hallucinations or delusions, and sensitivity of 32% and specificity 99% for identifying people in an early phase of psychosis (clinical high risk or first episode psychosis).
引用
收藏
页码:861 / 868
页数:8
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