Hypertension and Diabetes Mellitus Coprediction and Time Trajectories
被引:173
作者:
Tsimihodimos, Vasilis
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Univ Pisa, Dept Clin & Expt Med, Via Roma 67, I-56100 Pisa, ItalyUniv Pisa, Dept Clin & Expt Med, Via Roma 67, I-56100 Pisa, Italy
Tsimihodimos, Vasilis
[1
]
Gonzalez-Villalpando, Clicerio
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机构:
Inst Nacl Salud Publ, Ctr Invest Salud Poblac, Unidad Invest Diabet & Riesgo Cardiovasc, Ctr Estudios Diabet, Mexico City, DF, MexicoUniv Pisa, Dept Clin & Expt Med, Via Roma 67, I-56100 Pisa, Italy
Gonzalez-Villalpando, Clicerio
[2
]
Meigs, James B.
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Massachusetts Gen Hosp, Div Gen Internal Med Div, Boston, MA 02114 USA
Harvard Med Sch, Dept Med, Boston, MA USAUniv Pisa, Dept Clin & Expt Med, Via Roma 67, I-56100 Pisa, Italy
Meigs, James B.
[3
,4
]
Ferrannini, Ele
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CNR, Inst Clin Physiol, Pisa, ItalyUniv Pisa, Dept Clin & Expt Med, Via Roma 67, I-56100 Pisa, Italy
Ferrannini, Ele
[5
]
机构:
[1] Univ Pisa, Dept Clin & Expt Med, Via Roma 67, I-56100 Pisa, Italy
Type 2 diabetes mellitus and hypertension overlap in the population. In many subjects, development of diabetes mellitus is characterized by a relatively rapid increase in plasma glucose values. Whether a similar phenomenon occurs during the development of hypertension is not known. We analyzed the pattern of blood pressure (BP) changes during the development of hypertension in patients with or without diabetes mellitus using data from the MCDS (Mexico City Diabetes Study; a population-based study of diabetes mellitus in Hispanic whites) and in the FOS (Framingham Offspring Study, a community-based study in non-Hispanic whites) during a 7-year follow-up. Diabetes mellitus at baseline was a significant predictor of incident hypertension (in FOS, odds ratio, 3.14; 95% confidence interval, 2.17-4.54) independently of sex, age, body mass index, and familial diabetes mellitus. Conversely, hypertension at baseline was an independent predictor of incident diabetes mellitus (in FOS, odds ratio, 3.33; 95% CI, 2.50-4.44). In >60% of the converters, progression from normotension to hypertension was characterized by a steep increase in BP values, averaging 20 mm Hg for systolic BP within 3.5 years (in MCDS). In comparison with the nonconverters group, hypertension and diabetes mellitus converters shared a metabolic syndrome phenotype (hyperinsulinemia, higher body mass index, waist girth, BP, heart rate and pulse pressure, and dyslipidemia). Overall, results were similar in the 2 ethnic groups. We conclude that (1) development of hypertension and diabetes mellitus track each other over time, (2) transition from normotension to hypertension is characterized by a sharp increase in BP values, and (3) insulin resistance is one common feature of both prediabetes and prehypertension and an antecedent of progression to 2 respective disease states.
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页码:422 / 428
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[1]
Anfossi Giovanni, 2009, Archives of Physiology and Biochemistry, V115, P199, DOI 10.1080/13813450903136791
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MedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Georgetown Univ, Sch Med, Div Endocrinol Diabet & Metab, Washington, DC 20057 USA
George Washington Univ, Biostat Ctr, 6110 Executive Blvd,Suite 750, Rockville, MD 20852 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Aroda, Vanita R.
;
Knowler, William C.
论文数: 0引用数: 0
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NIDDK, Diabet Epidemiol & Clin Res Sect, Phoenix Epidemiol & Clin Res Branch, Phoenix, AZ USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Knowler, William C.
;
Crandall, Jill P.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Med, Div Endocrinol, New York, NY USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Crandall, Jill P.
;
Perreault, Leigh
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Sch Med, Div Endocrinol Metab & Diabet, Denver, CO USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Perreault, Leigh
;
Edelstein, Sharon L.
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George Washington Univ, Biostat Ctr, 6110 Executive Blvd,Suite 750, Rockville, MD 20852 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Edelstein, Sharon L.
;
Jeffries, Susan L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Jeffries, Susan L.
;
Molitch, Mark E.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Molitch, Mark E.
;
Pi-Sunyer, Xavier
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, New York, NY USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Pi-Sunyer, Xavier
;
Darwin, Christine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Los Angeles Med Ctr, Los Angeles, CA USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Darwin, Christine
;
Heckman-Stoddard, Brandy M.
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Div Canc Prevent, Bethesda, MD 20892 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Heckman-Stoddard, Brandy M.
;
Temprosa, Marinella
论文数: 0引用数: 0
h-index: 0
机构:
George Washington Univ, Biostat Ctr, 6110 Executive Blvd,Suite 750, Rockville, MD 20852 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Temprosa, Marinella
;
Kahn, Steven E.
论文数: 0引用数: 0
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机构:
VA Puget Sound Hlth Care Syst, Seattle, WA USA
Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, Seattle, WA 98195 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Kahn, Steven E.
;
Nathan, David M.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Diabet Unit, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Nathan, David M.
;
Grp, Diabet Prevention Program Res
论文数: 0引用数: 0
h-index: 0
机构:MedStar Hlth Res Inst, Hyattsville, MD 20782 USA
机构:
Univ Texas Hlth Sci Ctr San Antonio, Div Cardiol, San Antonio, TX 78229 USAUniv Texas Hlth Sci Ctr San Antonio, Div Cardiol, San Antonio, TX 78229 USA
Chilton, Robert
;
Tikkanen, Ilkka
论文数: 0引用数: 0
h-index: 0
机构:
Univ Helsinki, Helsinki Univ Hosp, Dept Nephrol, Helsinki, Finland
Minerva Fdn, Helsinki, FinlandUniv Texas Hlth Sci Ctr San Antonio, Div Cardiol, San Antonio, TX 78229 USA
Tikkanen, Ilkka
;
Hehnke, Uwe
论文数: 0引用数: 0
h-index: 0
机构:
Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, GermanyUniv Texas Hlth Sci Ctr San Antonio, Div Cardiol, San Antonio, TX 78229 USA
Hehnke, Uwe
;
Woerle, Hans J.
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Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, GermanyUniv Texas Hlth Sci Ctr San Antonio, Div Cardiol, San Antonio, TX 78229 USA
Woerle, Hans J.
;
Johansen, Odd Erik
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Boehringer Ingelheim Norway KS, Asker, NorwayUniv Texas Hlth Sci Ctr San Antonio, Div Cardiol, San Antonio, TX 78229 USA
机构:
Univ Oxford, George Inst Global Hlth, Oxford OX1 3DB, EnglandUniv Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
Emdin, Connor A.
;
Anderson, Simon G.
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Univ Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
Univ Manchester, Inst Cardiovasc Sci, Cardiovasc Res Grp, Manchester, Lancs, EnglandUniv Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
Anderson, Simon G.
;
Woodward, Mark
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Univ Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
Univ Sydney, George Inst Global Hlth, Sydney, NSW 2006, AustraliaUniv Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
Woodward, Mark
;
Rahimi, Kazem
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Univ Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford OX1 3DB, EnglandUniv Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
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Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA
Han, Cheng
;
Wu, Wenhe
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Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA
Wenzhou Med Univ, Key Lab Lab Med, Zhejiang Prov Key Lab Med Genet, Wenzhou 325035, Zhejiang, Peoples R ChinaAlbert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA
Wu, Wenhe
;
Ale, Albert
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Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA
Ale, Albert
;
Kim, Min Soo
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Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA
Kim, Min Soo
;
Cai, Dongsheng
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Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA
机构:
MedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Georgetown Univ, Sch Med, Div Endocrinol Diabet & Metab, Washington, DC 20057 USA
George Washington Univ, Biostat Ctr, 6110 Executive Blvd,Suite 750, Rockville, MD 20852 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Aroda, Vanita R.
;
Knowler, William C.
论文数: 0引用数: 0
h-index: 0
机构:
NIDDK, Diabet Epidemiol & Clin Res Sect, Phoenix Epidemiol & Clin Res Branch, Phoenix, AZ USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Knowler, William C.
;
Crandall, Jill P.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Med, Div Endocrinol, New York, NY USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Crandall, Jill P.
;
Perreault, Leigh
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Sch Med, Div Endocrinol Metab & Diabet, Denver, CO USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Perreault, Leigh
;
Edelstein, Sharon L.
论文数: 0引用数: 0
h-index: 0
机构:
George Washington Univ, Biostat Ctr, 6110 Executive Blvd,Suite 750, Rockville, MD 20852 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Edelstein, Sharon L.
;
Jeffries, Susan L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Jeffries, Susan L.
;
Molitch, Mark E.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Molitch, Mark E.
;
Pi-Sunyer, Xavier
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, New York, NY USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Pi-Sunyer, Xavier
;
Darwin, Christine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Los Angeles Med Ctr, Los Angeles, CA USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Darwin, Christine
;
Heckman-Stoddard, Brandy M.
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Div Canc Prevent, Bethesda, MD 20892 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Heckman-Stoddard, Brandy M.
;
Temprosa, Marinella
论文数: 0引用数: 0
h-index: 0
机构:
George Washington Univ, Biostat Ctr, 6110 Executive Blvd,Suite 750, Rockville, MD 20852 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Temprosa, Marinella
;
Kahn, Steven E.
论文数: 0引用数: 0
h-index: 0
机构:
VA Puget Sound Hlth Care Syst, Seattle, WA USA
Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, Seattle, WA 98195 USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Kahn, Steven E.
;
Nathan, David M.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Diabet Unit, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA USAMedStar Hlth Res Inst, Hyattsville, MD 20782 USA
Nathan, David M.
;
Grp, Diabet Prevention Program Res
论文数: 0引用数: 0
h-index: 0
机构:MedStar Hlth Res Inst, Hyattsville, MD 20782 USA
机构:
Univ Texas Hlth Sci Ctr San Antonio, Div Cardiol, San Antonio, TX 78229 USAUniv Texas Hlth Sci Ctr San Antonio, Div Cardiol, San Antonio, TX 78229 USA
Chilton, Robert
;
Tikkanen, Ilkka
论文数: 0引用数: 0
h-index: 0
机构:
Univ Helsinki, Helsinki Univ Hosp, Dept Nephrol, Helsinki, Finland
Minerva Fdn, Helsinki, FinlandUniv Texas Hlth Sci Ctr San Antonio, Div Cardiol, San Antonio, TX 78229 USA
Tikkanen, Ilkka
;
Hehnke, Uwe
论文数: 0引用数: 0
h-index: 0
机构:
Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, GermanyUniv Texas Hlth Sci Ctr San Antonio, Div Cardiol, San Antonio, TX 78229 USA
Hehnke, Uwe
;
Woerle, Hans J.
论文数: 0引用数: 0
h-index: 0
机构:
Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, GermanyUniv Texas Hlth Sci Ctr San Antonio, Div Cardiol, San Antonio, TX 78229 USA
Woerle, Hans J.
;
Johansen, Odd Erik
论文数: 0引用数: 0
h-index: 0
机构:
Boehringer Ingelheim Norway KS, Asker, NorwayUniv Texas Hlth Sci Ctr San Antonio, Div Cardiol, San Antonio, TX 78229 USA
机构:
Univ Oxford, George Inst Global Hlth, Oxford OX1 3DB, EnglandUniv Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
Emdin, Connor A.
;
Anderson, Simon G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
Univ Manchester, Inst Cardiovasc Sci, Cardiovasc Res Grp, Manchester, Lancs, EnglandUniv Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
Anderson, Simon G.
;
Woodward, Mark
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
Univ Sydney, George Inst Global Hlth, Sydney, NSW 2006, AustraliaUniv Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
Woodward, Mark
;
Rahimi, Kazem
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford OX1 3DB, EnglandUniv Oxford, George Inst Global Hlth, Oxford OX1 3DB, England
机构:
Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA
Han, Cheng
;
Wu, Wenhe
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA
Wenzhou Med Univ, Key Lab Lab Med, Zhejiang Prov Key Lab Med Genet, Wenzhou 325035, Zhejiang, Peoples R ChinaAlbert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA
Wu, Wenhe
;
Ale, Albert
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA
Ale, Albert
;
Kim, Min Soo
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA
Kim, Min Soo
;
Cai, Dongsheng
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA