IMMUNOHISTOCHEMICAL DETECTION OF ESTROGEN AND PROGESTERONE RECEPTORS IN THE HUMAN LACRIMAL GLAND

被引:4
作者
Gligorijevic, Jasmina [1 ]
Krstic, M. [1 ]
Babic, Gordana [2 ]
机构
[1] Fac Med, Inst Pathol, Nish 18000, Serbia
[2] Fac Med, Clin Eye Dis, Nish 18000, Serbia
关键词
Estrogen; progesterone; receptor; lacrimal gland; immunohistochemistry; HORMONE REPLACEMENT THERAPY; TEAR FUNCTION; POSTMENOPAUSAL WOMEN; ANDROGEN RECEPTORS; IDENTIFICATION; DEFICIENCY; EYE; KERATOCONJUNCTIVITIS; EXPRESSION;
D O I
10.2298/ABS1102319G
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The nature and extent of estrogen and progesterone action on the lacrimal gland is not known, and neither are the targets for their action. Immunohistochemical detection of estrogen and progesterone receptors in the human lacrimal glands in both sexes in different age groups was performed in this study. Twenty human lacrimal glands from autopsies were analyzed by the immunohistochemical method of cell counting and the chi(2) test. Estrogen and progesterone receptors were detected in the lacrimal glands of both sexes with significantly higher total and average cell counts in females (p<0,001). Estrogen and progesterone receptors are present in human lacrimal glands with age and gender dependent expression.
引用
收藏
页码:319 / 324
页数:6
相关论文
共 25 条
[1]   Estrogen prevention of lacrimal gland cell death and lymphocytic infiltration [J].
Azzarolo, AM ;
Eihausen, H ;
Schechter, J .
EXPERIMENTAL EYE RESEARCH, 2003, 77 (03) :347-354
[2]   ESTROGEN AND PROGESTERONE RECEPTORS IN VERNAL KERATOCONJUNCTIVITIS [J].
BONINI, S ;
LAMBIASE, A ;
SCHIAVONE, M ;
CENTOFANTI, M ;
PALMA, LA ;
BONINI, S .
OPHTHALMOLOGY, 1995, 102 (09) :1374-1379
[3]   THE STEROID-RECEPTOR SUPERFAMILY - MECHANISMS OF DIVERSITY [J].
FULLER, PJ .
FASEB JOURNAL, 1991, 5 (15) :3092-3099
[4]  
KRAMER P, 1990, OPHTHALMOLOGY, V97, P303
[5]   Effect of androgen deficiency on the human meibomian gland and ocular surface [J].
Krenzer, KL ;
Dana, MR ;
Ullman, MD ;
Cermak, JM ;
Tolls, DB ;
Evans, JE ;
Sullivan, DA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (12) :4874-4882
[6]   Tear function changes of postmenopausal women in response to hormone replacement therapy [J].
Kuscu, NK ;
Toprak, AB ;
Vatansever, S ;
Koyuncu, FM ;
Guler, C .
MATURITAS, 2003, 44 (01) :63-68
[7]   Menopause and tear function: The influence of prolactin and sex hormones on human tear production [J].
Mathers, WD ;
Stovall, D ;
Lane, JA ;
Zimmerman, MB ;
Johnson, S .
CORNEA, 1998, 17 (04) :353-358
[8]   Hormonal support of lacrimal function, primary lacrimal deficiency, autoimmunity, and peripheral tolerance in the lacrimal gland [J].
Mircheff, AK ;
Warren, DW ;
Wood, RL .
OCULAR IMMUNOLOGY AND INFLAMMATION, 1996, 4 (03) :145-172
[9]  
MUTANT C, BR J OPHTALMOL, V85, P877
[10]   Unraveling the Pathophysiology of Sjogren Syndrome-Associated Dry Eye Disease [J].
Nguyen, Cuong Q. ;
Peck, Ammon B. .
OCULAR SURFACE, 2009, 7 (01) :11-27