Synergistic Anticancer Effects Achieved by Co-Delivery of TRAIL and Paclitaxel Using Cationic Polymeric Micelles

被引：46

作者：

Lee, Ashlynn L. Z. ^{[1
,2
]}

Wang, Yong ^{[1
]}

Pervaiz, Shazib ^{[2
]}

Fan, Weimin ^{[3
]}

Yang, Yi Yan ^{[1
]}

机构：

[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore 117597, Singapore

[3] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China

来源：

MACROMOLECULAR BIOSCIENCE | 2011年 / 11卷 / 02期

关键词：

drug delivery systems; nanoparticles; protein delivery; self-assembly; synergistic effects; APOPTOSIS-INDUCING LIGAND; CHEMOTHERAPEUTIC-AGENTS; HUMAN HEPATOCYTES; CANCER-CELLS; IN-VIVO; DRUGS; NANOPARTICLES; PATHWAY; PROTEIN; DEATH;

D O I：

10.1002/mabi.201000332

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cationic micellar nanoparticles self-assembled from a biodegradable amphiphilic copolymer have been used to deliver human TRAIL and paclitaxel simultaneously. Polyplexes formed between paclitaxel-loaded nanoparticles and TRAIL are stable with a size of approximate to 180 nm and a zeta potential at approximate to 75 mV. Anticancer effects and apoptotic pathway mechanisms of this drug-and-protein co-delivery system are investigated in various human breast cancer cell lines with different TRAIL sensitivity. The co-delivery nanoparticulate system induces synergistic anti-cancer activities with limited toxicity in non-cancerous cells. An advantage of this co-delivery is a significantly higher anti-cancer effect as compared to free drug and protein formulations.

引用

页码：296 / 307

页数：12

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