In vitro and in vivo activities of DA-7867, a new oxazolidinone, against aerobic gram-positive bacteria

被引：7
作者：
Yoon, EJ
Jo, YW
Choi, SH
Lee, TH
Rhee, JK
Yoo, M
Shim, MJ
Choi, EC
机构：
[1] Seoul Natl Univ, Dept Microbiol, Coll Pharm, Seoul 151742, South Korea
[2] Seoul Natl Univ, Dept Microbiol, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
[3] Dong A Pharm Co Ltd, Res Lab, Yongin 449905, South Korea
[4] Univ Seoul, Dept Life Sci, Seoul 130743, South Korea
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 06期
关键词：
D O I：
10.1128/AAC.49.6.2498-2500.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In vitro and in vivo activities of DA-7867 were assessed against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and penicillin-resistant Streptococcuspneumoniae. All isolates were inhibited by DA-7867 at :50.78 mu g/ml, a four-times-lower concentration than that of inhibition by linezolid. For murine infection models, DA-7867 also exhibited greater efficacy than linezolid against all isolates tested.
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收藏
页码：2498 / 2500
页数：3
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