Sex Differences in Immunity to Viral Infections

被引：143

作者：

Jacobsen, Henning ^{[1
]}

Klein, Sabra L. ^{[1
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 02114 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

关键词：

inflammation; innate immunity; T cells; antibodies; SARS-CoV-2; influenza; RESPIRATORY SYNDROME CORONAVIRUS; B-CELL RESPONSES; DENDRITIC CELLS; T-CELLS; LYMPHOCYTE SUBSETS; GENDER-DIFFERENCES; UNITED-STATES; X-CHROMOSOME; CUTTING EDGE; DISEASE; 2019;

D O I：

10.3389/fimmu.2021.720952

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following SARS-CoV-2 infection. Strong evidence of a male bias in COVID-19 disease severity is hypothesized to be mediated by sex differential immune responses against SARS-CoV-2. This hypothesis is based on data from other viral infections, including influenza viruses, HIV, hepatitis viruses, and others that have demonstrated sex-specific immunity to viral infections. Although males are more susceptible to most viral infections, females possess immunological features that render them more vulnerable to distinct immune-related disease outcomes. Both sex chromosome complement and related genes as well as sex steroids play important roles in mediating the development of sex differences in immunity to viral infections.</p>

引用

页数：11

共 175 条

[91] Genetic variation in chromosome Y regulates susceptibility to influenza A virus infection [J].

Krementsov, Dimitry N. ;

Case, Laure K. ;

Dienz, Oliver ;

Raza, Abbas ;

Fang, Qian ;

Ather, Jennifer L. ;

Poynter, Matthew E. ;

Boyson, Jonathan E. ;

Bunn, Janice Y. ;

Teuscher, Cory .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (13) :3491-3496

[92]

Lee BW, 1996, CYTOMETRY, V26, P8, DOI 10.1002/(SICI)1097-0320(19960315)26:1<8::AID-CYTO2>3.0.CO

[93]

2-E

[94] Progesterone Promotes Differentiation of Human Cord Blood Fetal T Cells into T Regulatory Cells but Suppresses Their Differentiation into Th17 Cells [J].

Lee, Jee H. ;

Ulrich, Benjamin ;

Cho, Jungyoon ;

Park, Jeongho ;

Kim, Chang H. .

JOURNAL OF IMMUNOLOGY, 2011, 187 (04) :1778-1787

[95]

Leong HN, 2006, ANN ACAD MED SINGAP, V35, P326

[96] URINARY-TRACT INFECTIONS IN MEN - EPIDEMIOLOGY, PATHO-PHYSIOLOGY, DIAGNOSIS, AND TREATMENT [J].

LIPSKY, BA .

ANNALS OF INTERNAL MEDICINE, 1989, 110 (02) :138-150

[97] T-lymphocyte subsets in West African children: Impact of age, sex, and season [J].

Lisse, IM ;

Aaby, P ;

Whittle, H ;

Jensen, H ;

Engelmann, M ;

Christensen, LB .

JOURNAL OF PEDIATRICS, 1997, 130 (01) :77-85

[98]

Liu Chieh-An, 2003, Chang Gung Med J, V26, P561

[99] Transcriptional Differences for COVID-19 Disease Map Genes between Males and Females Indicate a Different Basal Immunophenotype Relevant to the Disease [J].

Liu, Tianyuan ;

Balzano-Nogueira, Leandro ;

Lleo, Ana ;

Conesa, Ana .

GENES, 2020, 11 (12) :1-14

[100] Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production [J].

Liva, SM ;

Voskuhl, RR .

JOURNAL OF IMMUNOLOGY, 2001, 167 (04) :2060-2067

← 5 6 7 8 9 10 11 12 13 14 →