Sex Differences in Immunity to Viral Infections

被引：141
作者：
Jacobsen, Henning [1 ]
Klein, Sabra L. [1 ]
机构：
[1] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 02114 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
关键词：
inflammation; innate immunity; T cells; antibodies; SARS-CoV-2; influenza; RESPIRATORY SYNDROME CORONAVIRUS; B-CELL RESPONSES; DENDRITIC CELLS; T-CELLS; LYMPHOCYTE SUBSETS; GENDER-DIFFERENCES; UNITED-STATES; X-CHROMOSOME; CUTTING EDGE; DISEASE; 2019;
D O I：
10.3389/fimmu.2021.720952
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following SARS-CoV-2 infection. Strong evidence of a male bias in COVID-19 disease severity is hypothesized to be mediated by sex differential immune responses against SARS-CoV-2. This hypothesis is based on data from other viral infections, including influenza viruses, HIV, hepatitis viruses, and others that have demonstrated sex-specific immunity to viral infections. Although males are more susceptible to most viral infections, females possess immunological features that render them more vulnerable to distinct immune-related disease outcomes. Both sex chromosome complement and related genes as well as sex steroids play important roles in mediating the development of sex differences in immunity to viral infections.</p>
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页数：11
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