An Autopsy Case of Antibody-negative Immune-mediated Necrotizing Myopathy with Severe Cardiac Involvement

被引：3
作者：
Tamura, Takumi [1 ]
Miyajima, Keisuke [2 ]
Watanabe, Kazuki [3 ]
Ito, Kazuki [2 ]
Kin, Fumihiko [2 ]
Okazaki, Ayako [2 ]
Takashima, Yasuyo [2 ]
Watanabe, Tomoyuki [2 ]
Kawaguchi, Yoshitaka [2 ]
Wakabayashi, Yasushi [2 ]
Miyajima, Hiroaki [3 ]
Maekawa, Yuichiro [1 ]
机构：
[1] Hamamatsu Univ Sch Med, Div Cardiol, Internal Med 3, Shizuoka, Japan
[2] Seirei Mikatahara Gen Hosp, Dept Cardiol, Shizuoka, Japan
[3] Hamamatsu Univ Sch Med, Div Neurol, Internal Med 1, Shizuoka, Japan
来源：
INTERNAL MEDICINE | 2021年 / 60卷 / 19期
关键词：
immune-mediated necrotizing myopathy; secondary cardiomyopathy; cardiac magnetic resonance imaging; autopsy;
D O I：
10.2169/internalmedicine.6355-20
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 41-year-old man was admitted with a chief complaint of dyspnea. Echocardiography showed diffuse severe hypokinesis in the left ventricle. Although his heart failure improved, high creatine kinase levels persisted. A muscle biopsy of the biceps brachii showed necrotic and regenerating fibers along with positive findings for major histocompatibility complex class I and membrane attack complex. He was diagnosed with antibody-negative immune-mediated necrotizing myopathy (IMNM). Steroid therapy was started, but he died due to ventricular fibrillation. Autopsy findings revealed CD68-positive macrophages in the myocardium and quadriceps. To our knowledge, this is the first case of antibody-negative IMNM with cardiac involvement.
引用
收藏
页码：3113 / 3119
页数：7
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